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A gene on chromosome 20q12-q13.12 that encodes a coregulator for alpha and beta oestrogen.
Molecular pathology
NCOA4 to RET translocations have been associated with papillary thyroid carcinoma.
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Mode of presentation was classic triad of pain in flank, palpable mass and hematuria in 12 (8%), pain in flank in 40 (26%), palpable mass in eight (5.33%), hematuria in 20 (13.33%), and non-specific symptoms in 70 (46.66%) patients.
(1) The classic triad (polyuria, polydipsia, and weight loss) is the commonest presenting symptom of diabetes in children.
The classic triad of symptoms--gait disturbance, cognitive dysfunction, and urinary incontinence--generally responds to treatment if present for less than 2 years' duration.
An often-missed diagnosis, it should be suspected in any patient with the classic triad: pregnancy loss at 14-16 weeks, retroverted/retroflexed uterus associated with large fibroids and/or adhesions, and normal placental histology.
The classic triad he formed with legendary trainer Vincent O'Brien and stud boss John Magnier left a legacy that still exists, with the Coolmore operation preeminent in the world of breeding.
Urethritis, arthritis, and conjunctivitis form the classic triad of symptom of Reiter's syndrome.
The classic triad for FES is pulmonary insufficiency, neurologic abnormalities, and petechial rash, and Gurd's criteria are commonly used.
The classic triad of neurogenic shock includes hypotension, bradycardia and hypothermia.
I n the clinical presentation of Wernicke's encephalopathy, the typical classic triad of ataxia, confusion and nystagmus is present in less than half of all patients.
The diagnosis of KS was based on the demonstration of the classic triad of the syndrome, consisting of bronchiectasis, paranasal sinusitis and SIT.
On IVP, the classic triad includes delay of contrast material with unilateral (20%) or bilateral (68%) hydronephrosis, medial deviation of the middle third of the ureters, as depicted in the image below, and tapering of the ureters at the level of L4/L5 vertebrae.[9,10] Up to 18%-20% of control subjects may show this triad.[11]
Abdominal pain, peripheral neuropathy, and changes in mental status are the classic triad featured in an acute attack.

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