HES6(redirected from Class B basic helix-loop-helix protein 41)
HES6A gene on chromosome 2q37.3 that encodes a transcription repressor which, while not binding DNA, suppresses HES1-mediated N-box-dependent transcriptional repression and the binding of HES1 to E-box sequences. HES6 also suppresses HES1-mediated inhibition of the ASCL1/MASH1 and TCF3/E47 heterodimer, allowing ASCL1 and TCF3 to upregulate transcription. It promotes cell differentiation.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.