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Clarke-Hadfield syndrome[klark had´fēld]
congenital pancreatic infantilism, with hepatomegaly, bulky stools, and extensive atrophy of the pancreas in an undersized and underweight child.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
cys·tic fi·bro·sis, cystic fibrosis of the pancreas [MIM*219700]
a congenital metabolic disorder in which secretions of exocrine glands are abnormal; excessively viscid mucus causes obstruction of passageways (including pancreatic and bile ducts, intestines, and bronchi), and the sodium and chloride content of sweat is increased throughout the patient's life; symptoms usually appear in childhood and include meconium ileus, poor growth despite good appetite, malabsorption and foul bulky stools, chronic bronchitis with cough, recurrent pneumonia, bronchiectasis, emphysema, clubbing of the fingers, and salt depletion in hot weather. Detailed genetic mapping and molecular biology have been accomplished by the methods of reverse genetics; autosomal recessive inheritance, caused by mutation in the cystic fibrosis conductance regulator gene (CFTR) on chromosome 7q.
Synonym(s): Clarke-Hadfield syndrome, fibrocystic disease of the pancreas, mucoviscidosis, viscidosis
Farlex Partner Medical Dictionary © Farlex 2012
[Cecil Clarke, 20th-cent. Brit. physician; Geoffrey John Hadfield, Brit. pathologist, 1899–1968]
An infrequently used eponym for cystic fibrosis.See: cystic fibrosis
Medical Dictionary, © 2009 Farlex and Partners
Clarke,Cecil, 20th century English physician.
Clarke-Hadfield syndrome - a congenital metabolic disorder in which secretions of exocrine glands are abnormal. Synonym(s): cystic fibrosis
Hadfield,Geoffrey, English physician, 1889-1968.
Clarke-Hadfield syndrome - see under Clarke, Cecil
Medical Eponyms © Farlex 2012