Breslow's depth of invasion (measured in hundredths of a millimeter) and Clark's level
of invasion into the layers of the dermis (papillary dermis, reticular dermis, and subcutaneous layer) are both important components of the diagnosis, as they guide therapy and yield prognostic information.
He remained well with regard to the melanoma until 2005 when, at the age of 69, he had a second primary melanoma removed from his back, Breslow thickness 9mm, Clark's level V, with no ulceration but areas of focal regression were seen.
2mm in Breslow thickness, Clark's level IV, with no ulceration, areas of regression and a brisk tumour infiltrating lymphocyte reaction were seen.
A 41-year-old man had a superficial spreading melanoma in situ, Clark's level I, removed from his anterior abdominal wall.
A retrospective case-controlled study of HIV-positive and HIV-negative patients with melanoma matched the patients for melanoma subtype, Breslow thickness, Clark's level, tumour location, gender and age, and found that HIV-positive patients with malignant melanoma had a significantly reduced disease-free and overall survival .