Clark's level

Clark's level

(klärks)
n.
Any of four levels that mark the invasion of malignant melanoma through the skin layers to the subcutaneous fat layer, each successive level indicating a worsening prognosis.
References in periodicals archive ?
The other variables, Clark's level, histological type, tumor location, ulceration and number of SLN harvested, were not significantly correlated with positive SLN status.
The pattern of worse outcomes in melanoma patients with a history of CLL was significant across all categories of Breslow tumor depth and Clark's level, but it was most striking in patients with thicker lesions.
Histological examination with haemotoxylin and eosin staining was interpreted by the pathologist to be consistent with a 6 mm deep, Clark's level 5 melanoma.
Nodular Malignant Melanoma, stage II, Clark's Level IV, with some lymphatic infiltrate.
Breslow's depth of invasion (measured in hundredths of a millimeter) and Clark's level of invasion into the layers of the dermis (papillary dermis, reticular dermis, and subcutaneous layer) are both important components of the diagnosis, as they guide therapy and yield prognostic information.
He remained well with regard to the melanoma until 2005 when, at the age of 69, he had a second primary melanoma removed from his back, Breslow thickness 9mm, Clark's level V, with no ulceration but areas of focal regression were seen.
Tis: Melanoma in situ (including atypical melanocytic hyperplasia, severe melanocytic dysplasia); Clark's Level I.
It is often useful to have a Breslow thickness and a Clark's level for primary cutaneous melanomas (both methods are used for staging thin primary lesions).
Previously identified risk factors for metastatic disease include male gender, body site, Breslow thickness, Clark's level, vertical growth phase, microscopic satellites, and ulceration.
Histopathology showed a superficial spreading Clark's level IV melanoma, with a depth of 1.
SAN DIEGO -- Even melanomas thinner than 1 mm may warrant a sentinel node biopsy when there is ulceration, evidence of regression, or a Clark's level greater than LV, Dr.
New criteria for staging melanoma will drop Clark's level as a prognostic factor for all but thin melanomas, Dr.