The other variables, Clark's level
, histological type, tumor location, ulceration and number of SLN harvested, were not significantly correlated with positive SLN status.
The pattern of worse outcomes in melanoma patients with a history of CLL was significant across all categories of Breslow tumor depth and Clark's level
, but it was most striking in patients with thicker lesions.
Histological examination with haemotoxylin and eosin staining was interpreted by the pathologist to be consistent with a 6 mm deep, Clark's level
Nodular Malignant Melanoma, stage II, Clark's Level
IV, with some lymphatic infiltrate.
Breslow's depth of invasion (measured in hundredths of a millimeter) and Clark's level
of invasion into the layers of the dermis (papillary dermis, reticular dermis, and subcutaneous layer) are both important components of the diagnosis, as they guide therapy and yield prognostic information.
He remained well with regard to the melanoma until 2005 when, at the age of 69, he had a second primary melanoma removed from his back, Breslow thickness 9mm, Clark's level
V, with no ulceration but areas of focal regression were seen.
Tis: Melanoma in situ (including atypical melanocytic hyperplasia, severe melanocytic dysplasia); Clark's Level
It is often useful to have a Breslow thickness and a Clark's level
for primary cutaneous melanomas (both methods are used for staging thin primary lesions).
Previously identified risk factors for metastatic disease include male gender, body site, Breslow thickness, Clark's level
, vertical growth phase, microscopic satellites, and ulceration.
Histopathology showed a superficial spreading Clark's level
IV melanoma, with a depth of 1.
SAN DIEGO -- Even melanomas thinner than 1 mm may warrant a sentinel node biopsy when there is ulceration, evidence of regression, or a Clark's level
greater than LV, Dr.
New criteria for staging melanoma will drop Clark's level
as a prognostic factor for all but thin melanomas, Dr.