loratadine

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loratadine

 [lah-rat´ah-dēn]
a nonsedating antihistamine (H1 receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria and as a treatment adjunct in asthma; administered orally.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

loratadine

Aerius (CA), Alavert, Allertin, Claritin, Claritin RediTabs, Clarityn (UK)

Pharmacologic class: Histamine1-receptor antagonist (second-generation)

Therapeutic class: Antihistamine (nonsedating)

Pregnancy risk category B

Action

Selective histamine1-receptor antagonist. Blocks peripheral effects of histamine release during allergic reactions, decreasing or preventing allergy symptoms.

Availability

Syrup: 1 mg/ml

Tablets: 10 mg

Tablets (rapidly disintegrating): 10 mg

Indications and dosages

Seasonal allergies; chronic idiopathic urticaria

Adults and children ages 6 and older: 10 mg P.O. daily

Children ages 2 to 5: 5 mg P.O. daily

Dosage adjustment

• Renal or hepatic impairment

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:

• renal or hepatic impairment

• elderly patients

• pregnant patients

• children younger than age 2 (safety not established).

Administration

• Give once a day on empty stomach.

• Place rapidly disintegrating tablet on tongue; give with or without water.

• Use rapidly disintegrating tablets within 6 months of opening foil pouch and immediately after opening individual tablet blister.

Adverse reactions

CNS: headache, nervousness, insomnia

EENT: conjunctivitis, earache, epistaxis, pharyngitis

GI: abdominal pain; dry mouth; diarrhea, stomatitis (in children)

Skin: rash, photosensitivity, angioedema

Other: tooth disorder (in children), fever, flulike symptoms, viral infections

Interactions

Drug-food. Any food: increased drug absorption

Patient monitoring

• Watch for adverse reactions, especially in children.

• Assess patient's response to drug.

• Watch for new symptoms or exacerbation of existing symptoms.

Patient teaching

• Advise patient to take exactly as prescribed, once a day on empty stomach.

• Tell patient to report persistent or worsening symptoms.

• Instruct patient to report adverse reactions, such as headache or nervousness.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the foods mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

loratadine

(lôr-ăt′ə-dēn′)
n.
A nonsedating antihistamine, C22H23ClN2O2, used to treat allergic rhinitis and other allergic disorders.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

loratadine

An ANTIHISTAMINE drug used to treat hay fever and other allergic disorders.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

antihistamine 

Any substance that reduces the effect of histamine or blocks histamine receptors, usually the histamine 1 (H1) receptor. It is used in the treatment of allergic conjunctivitis and also in the temporary relief of minor allergic symptoms of the eye. Common agents include antazoline sulfate, azelastine hydrochloride, cetirizine, chlorphenamine, emedastine, epinastine hydrochloride, ketotifen, levocabastine, loratadine and olopatadine. See hypersensitivity; mast cell stabilizers.
Millodot: Dictionary of Optometry and Visual Science, 7th edition. © 2009 Butterworth-Heinemann
References in periodicals archive ?
P-medicine and GSL oral solutions of most of the antihistamines are also available to facilitate this low dosing (ie, half a spoonful for a child), eg, Allerief (chlorphenamine), Benadryl Allergy Oral Syrup (cetirizine), Benadryl for Children Allergy Solution, Clarityn Allergy Syrup (loartidine), Piriteze Allergy Syrup, Zirtek Allergy Solution and Zirtek Allergy Relief for Children (cetirizine).
The first generation drugs often caused drowsiness but the more recent, second generation drugs such as Zirtec, Clarityn and Triludan, are much less sedating.
The Clarityn Allergy Guide to Summer Survival gives advice on treatment.
For example, the antihistamine Loratadine is particularly useful when the pollen count starts increasing, and is the core part of Clarityn's Allergy tablets.
Waitrose sells a 30 pack of Clarityn containing 10mg of cetirizine dihydrochloride for PS9.99 while Wilko's own brand again costs PS1.50.
A packet of 30 Clarityn hayfever and allergy tablets costs PS9 at Sainsbury's.
HAY FEVER MEDICATION SAVE: "COMMON antihistamines in hay fever medication include loratadine and cetirizine, yet popular brands, like Clarityn and Zirtek, are vastly more expensive.
1 CLARITYN RAPIDE (inset), PS5.99 for 10, from pharmacies PROVIDES speedy and effective all-day relief from airborne allergies, such as pollen and pet hair, and eases allergic skin conditions.
The newer ones like Clarityn, Zirtek and Benadryl are less likely to cause drowsiness and have fewer side effects.
The medications are Clarityn, Clarityn-S and Versal and the prescription-only drug Aerius.
Treatments: Clarityn (non-drowsy, one a day); Piriton (may cause drowsiness) or Anthisan (antihistamine cream).