loratadine

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loratadine

 [lah-rat´ah-dēn]
a nonsedating antihistamine (H1 receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria and as a treatment adjunct in asthma; administered orally.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

loratadine

Aerius (CA), Alavert, Allertin, Claritin, Claritin RediTabs, Clarityn (UK)

Pharmacologic class: Histamine1-receptor antagonist (second-generation)

Therapeutic class: Antihistamine (nonsedating)

Pregnancy risk category B

Action

Selective histamine1-receptor antagonist. Blocks peripheral effects of histamine release during allergic reactions, decreasing or preventing allergy symptoms.

Availability

Syrup: 1 mg/ml

Tablets: 10 mg

Tablets (rapidly disintegrating): 10 mg

Indications and dosages

Seasonal allergies; chronic idiopathic urticaria

Adults and children ages 6 and older: 10 mg P.O. daily

Children ages 2 to 5: 5 mg P.O. daily

Dosage adjustment

• Renal or hepatic impairment

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:

• renal or hepatic impairment

• elderly patients

• pregnant patients

• children younger than age 2 (safety not established).

Administration

• Give once a day on empty stomach.

• Place rapidly disintegrating tablet on tongue; give with or without water.

• Use rapidly disintegrating tablets within 6 months of opening foil pouch and immediately after opening individual tablet blister.

Adverse reactions

CNS: headache, nervousness, insomnia

EENT: conjunctivitis, earache, epistaxis, pharyngitis

GI: abdominal pain; dry mouth; diarrhea, stomatitis (in children)

Skin: rash, photosensitivity, angioedema

Other: tooth disorder (in children), fever, flulike symptoms, viral infections

Interactions

Drug-food. Any food: increased drug absorption

Patient monitoring

• Watch for adverse reactions, especially in children.

• Assess patient's response to drug.

• Watch for new symptoms or exacerbation of existing symptoms.

Patient teaching

• Advise patient to take exactly as prescribed, once a day on empty stomach.

• Tell patient to report persistent or worsening symptoms.

• Instruct patient to report adverse reactions, such as headache or nervousness.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the foods mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

loratadine

(lôr-ăt′ə-dēn′)
n.
A nonsedating antihistamine, C22H23ClN2O2, used to treat allergic rhinitis and other allergic disorders.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

loratadine

An ANTIHISTAMINE drug used to treat hay fever and other allergic disorders.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

antihistamine 

Any substance that reduces the effect of histamine or blocks histamine receptors, usually the histamine 1 (H1) receptor. It is used in the treatment of allergic conjunctivitis and also in the temporary relief of minor allergic symptoms of the eye. Common agents include antazoline sulfate, azelastine hydrochloride, cetirizine, chlorphenamine, emedastine, epinastine hydrochloride, ketotifen, levocabastine, loratadine and olopatadine. See hypersensitivity; mast cell stabilizers.
Millodot: Dictionary of Optometry and Visual Science, 7th edition. © 2009 Butterworth-Heinemann
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"The day prior to agency's issuance of the ANDA acceptance for filing letter, we contacted FDA and were informed that no other Paragraph IV ANDA filing had been accepted for a generic version of Claritin-D 12-Hour," commented Larry Hsu, Ph.D., president and COO.
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(-0.7%) Market Dollar sales Dollar sales share (000) % change Private Label 37.6% $128,735 -2.3% Zyrtec 8.0% 27,336 -0.9% Claritin 5.3% 18,090 +4.7% Allegra 5.0% 17,059 +7.9% Claritin-D 4.7% 15,999 +1.6% Benadryl 4.2% 14,441 +2.5% Allegra-D 3.3% 11,221 -8.4% Mucinex DM 2.6% 8,774 +4.4% Mucinex 2.4% 8,349 -16.1% Zyrtec-D 2.4% 8,117 +12.7% TOTAL UNIT SALES * 81.7 mil.
Inc.'s Fuji QuickSnap 400 Flash onetime-use camera 2-pack or 35mm 400-speed film 5-pack, 120 exposures, selling for $7.99; 2-mg, 72-count store brand Nicotine Mint lozenges, selling for 50% off of Longs Everyday Price; and Schering-Plough HealthCare Products Inc.'s 30-count Claritin 24-hour allergy, or 20- to 30-count Redi-Tabs 24 hour, or 20-count Claritin-D 12 hour, selling for $19.99.
Drug Stores * Brand Manufacturer Dollar Sales Total Sales $469,103,680 Private Label -- 155,891,232 Zyrtec McNeil-PPC 23,558,382 Alka-Seltzer Plus Bayer 21,585,312 Mucinex DM Reckitt Benckiser 18,549,860 Mucinex Reckitt Benckiser 16,375,132 Claritin-D Bayer 15,538,700 Claritin Bayer 14,606,354 Mucinex Fast-Max Reckitt Benckiser 14,153,468 Mucinex D Reckitt Benckiser 13,770,820 Theraflu Novartis 13,245,921 Brand % Change Dollar % Change vs.
That led to the release of such products as Claritin and Claritin-D.
The company said its product is the store brand equivalent to Schering-Plough's Claritin-D 12hour extended-release tablets.
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to produce three versions of O-T-C loratadine, which a company spokesman says are the generic equivalents of Claritin-D 12 Hour, Claritin-D 24 hour and Claritin RediTabs.
Claritin tablets, which are to be taken once daily; Claritin RediTabs, orally disintegrating tablets also taken once a day; Claritin-D, a 24-hour extended-release version with decongestant; Claritin-D 12-hour, intended to be taken twice daily; and Claritin syrup, designed for children age 2 and older.