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Pharmacologic class: Histamine1-receptor antagonist (second-generation)
Therapeutic class: Antihistamine (nonsedating)
Pregnancy risk category B
Selective histamine1-receptor antagonist. Blocks peripheral effects of histamine release during allergic reactions, decreasing or preventing allergy symptoms.
Syrup: 1 mg/ml
Tablets: 10 mg
Tablets (rapidly disintegrating): 10 mg
Indications and dosages
➣ Seasonal allergies; chronic idiopathic urticaria
Adults and children ages 6 and older: 10 mg P.O. daily
Children ages 2 to 5: 5 mg P.O. daily
• Renal or hepatic impairment
• Hypersensitivity to drug
Use cautiously in:
• renal or hepatic impairment
• elderly patients
• pregnant patients
• children younger than age 2 (safety not established).
• Give once a day on empty stomach.
• Place rapidly disintegrating tablet on tongue; give with or without water.
• Use rapidly disintegrating tablets within 6 months of opening foil pouch and immediately after opening individual tablet blister.
CNS: headache, nervousness, insomnia
EENT: conjunctivitis, earache, epistaxis, pharyngitis
GI: abdominal pain; dry mouth; diarrhea, stomatitis (in children)
Skin: rash, photosensitivity, angioedema
Other: tooth disorder (in children), fever, flulike symptoms, viral infections
Drug-food. Any food: increased drug absorption
• Watch for adverse reactions, especially in children.
• Assess patient's response to drug.
• Watch for new symptoms or exacerbation of existing symptoms.
• Advise patient to take exactly as prescribed, once a day on empty stomach.
• Tell patient to report persistent or worsening symptoms.
• Instruct patient to report adverse reactions, such as headache or nervousness.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the foods mentioned above.
Alavert Allergy 24 Hour(trade name),
Alavert Children's Allergy(trade name),
Claritin 24-Hour Allergy(trade name),
Claritin Children's Allergy(trade name),
Claritin Liqui–Gels 24-Hour Allergy(trade name),
Claritin Reditabs 24 Hour Allergy(trade name),
Tavist ND Allergy(trade name)
Time/action profile (antihistaminic effects)
|PO||1–3 hr||8–12 hr||>24 hr|
Adverse Reactions/Side Effects
Central nervous system
- drowsiness (rare)
- paradoxical excitation
Ear, Eye, Nose, Throat
- blurred vision
- dry mouth
- GI upset
- weight gain
Drug-Drug interactionThe following interactions may occur, but are less likely to occur with loratidine than with more sedating antihistamines.MAO inhibitors may intensify and prolong effects of antihistamines.↑ CNS depression may occur with other CNS depressants, including alcohol, antidepressants, opioid analgesics, and sedative/hypnotics.Amiodarone may ↑ loratadine levels and ↑ risk of QTc interval prolongationKava-kava, valerian, or chamomile can ↑ CNS depression.
Renal ImpairmentOral (Adults) CCr <30 mL/min—10 mg every other day.
Hepatic ImpairmentOral (Adults) 10 mg every other day.
Availability (generic available)
- Assess allergy symptoms (rhinitis, conjunctivitis, hives) before and periodically during therapy.
- Assess lung sounds and character of bronchial secretions. Maintain fluid intake of 1500–2000 mL/day to decrease viscosity of secretions.
- Lab Test Considerations: May cause false-negative result on allergy skin testing.
Potential Nursing DiagnosesIneffective airway clearance (Indications)
Risk for injury (Adverse Reactions)
- Do not confuse Claritin (loratadine) with Claritin Eye (ketotifen fumarate).
- Oral: Administer once daily.
- For rapidly disintegrating tablets (Alavert, Claritin Reditabs)—place on tongue. Tablet disintegrates rapidly. May be taken with or without water.
- Instruct patient to take medication as directed.
- May cause dizziness or drowsiness. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.
- Caution patient to use sunscreen and protective clothing to prevent photosensitivity reactions.
- Advise patient to avoid taking alcohol or other CNS depressants concurrently with this drug.
- Advise patient that good oral hygiene, frequent rinsing of mouth with water, and sugarless gum or candy may minimize dry mouth. Patient should notify dentist if dry mouth persists >2 wk.
- Instruct patient to contact health care professional immediately if dizziness, fainting, or fast or irregular heartbeat occurs or if symptoms persist.
- Decrease in allergic symptoms.
- Management of chronic idiopathic urticaria.
- Management of hives.