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Related to Claritin: Benadryl


Aerius (CA), Alavert, Allertin, Claritin, Claritin RediTabs, Clarityn (UK)

Pharmacologic class: Histamine1-receptor antagonist (second-generation)

Therapeutic class: Antihistamine (nonsedating)

Pregnancy risk category B


Selective histamine1-receptor antagonist. Blocks peripheral effects of histamine release during allergic reactions, decreasing or preventing allergy symptoms.


Syrup: 1 mg/ml

Tablets: 10 mg

Tablets (rapidly disintegrating): 10 mg

Indications and dosages

Seasonal allergies; chronic idiopathic urticaria

Adults and children ages 6 and older: 10 mg P.O. daily

Children ages 2 to 5: 5 mg P.O. daily

Dosage adjustment

• Renal or hepatic impairment


• Hypersensitivity to drug


Use cautiously in:
• renal or hepatic impairment
• elderly patients
• pregnant patients
• children younger than age 2 (safety not established).


• Give once a day on empty stomach.
• Place rapidly disintegrating tablet on tongue; give with or without water.
• Use rapidly disintegrating tablets within 6 months of opening foil pouch and immediately after opening individual tablet blister.

Adverse reactions

CNS: headache, nervousness, insomnia

EENT: conjunctivitis, earache, epistaxis, pharyngitis

GI: abdominal pain; dry mouth; diarrhea, stomatitis (in children)

Skin: rash, photosensitivity, angioedema

Other: tooth disorder (in children), fever, flulike symptoms, viral infections


Drug-food.Any food: increased drug absorption

Patient monitoring

• Watch for adverse reactions, especially in children.
• Assess patient's response to drug.
• Watch for new symptoms or exacerbation of existing symptoms.

Patient teaching

• Advise patient to take exactly as prescribed, once a day on empty stomach.
• Tell patient to report persistent or worsening symptoms.
• Instruct patient to report adverse reactions, such as headache or nervousness.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the foods mentioned above.


(lor-a-ta-deen) ,

Alavert Allergy 24 Hour

(trade name),

Alavert Children's Allergy

(trade name),


(trade name),

Claritin 24-Hour Allergy

(trade name),

Claritin Children's Allergy

(trade name),

Claritin Liqui–Gels 24-Hour Allergy

(trade name),

Claritin Reditabs 24 Hour Allergy

(trade name),


(trade name),

Tavist ND Allergy

(trade name)


Therapeutic: antihistamines
Pregnancy Category: B


Relief of symptoms of seasonal allergies.Management of chronic idiopathic urticaria.Management of hives.


Blocks peripheral effects of histamine released during allergic reactions.

Therapeutic effects

Decreased symptoms of allergic reactions (nasal stuffiness; red, swollen eyes, itching).


Absorption: Rapidly absorbed after oral administration (80%).
Distribution: Unknown.
Protein Binding: Loratadine—97%; descarboethoxyloratadine—73–77%.
Metabolism and Excretion: Rapidly and extensively metabolized during first pass through the liver. Much is converted to descarboethoxyloratadine, an active metabolite.
Half-life: Loratadine—8.4 hr; descarboethoxyloratadine—28 hr.

Time/action profile (antihistaminic effects)

PO1–3 hr8–12 hr>24 hr


Contraindicated in: Hypersensitivity.
Use Cautiously in: Hepatic impairment or CCr <30 mL/min (↓ dose to 10 mg every other day); Lactation: Usually compatible with breast feeding (AAP); Obstetric / Pediatric: Pregnancy or children <2 yr (safety not established). Syrup contains sodium benzoate, avoid use in neonates; Geriatric: ↑ risk of adverse reactions.

Adverse Reactions/Side Effects

Central nervous system

  • confusion
  • drowsiness (rare)
  • paradoxical excitation

Ear, Eye, Nose, Throat

  • blurred vision


  • dry mouth
  • GI upset


  • photosensitivity
  • rash


  • weight gain


Drug-Drug interaction

The following interactions may occur, but are less likely to occur with loratidine than with more sedating antihistamines.MAO inhibitors may intensify and prolong effects of antihistamines.↑ CNS depression may occur with other CNS depressants, including alcohol, antidepressants, opioid analgesics, and sedative/hypnotics.Amiodarone may ↑ loratadine levels and ↑ risk of QTc interval prolongationKava-kava, valerian, or chamomile can ↑ CNS depression.


Oral (Adults and Children ≥6 yr) 10 mg once daily.
Oral (Children ≥2–5 yr) 5 mg once daily.

Renal Impairment

Oral (Adults) CCr <30 mL/min—10 mg every other day.

Hepatic Impairment

Oral (Adults) 10 mg every other day.

Availability (generic available)

Rapidly disintegrating tabletsmint: 10 mgOTC
Tablets: 10 mgOTC
Capsules: 10 mgOTC
Chewable tablets: 5 mgOTC (grape flavored)
Syrupgrape, fruit: 5 mg/5 mLOTC
In combination with: pseudoephedrine (Claritin-D)OTC. See combination drugs.

Nursing implications

Nursing assessment

  • Assess allergy symptoms (rhinitis, conjunctivitis, hives) before and periodically during therapy.
  • Assess lung sounds and character of bronchial secretions. Maintain fluid intake of 1500–2000 mL/day to decrease viscosity of secretions.
  • Lab Test Considerations: May cause false-negative result on allergy skin testing.

Potential Nursing Diagnoses

Ineffective airway clearance (Indications)
Risk for injury (Adverse Reactions)


  • Do not confuse Claritin (loratadine) with Claritin Eye (ketotifen fumarate).
  • Oral: Administer once daily.
    • For rapidly disintegrating tablets (Alavert, Claritin Reditabs)—place on tongue. Tablet disintegrates rapidly. May be taken with or without water.

Patient/Family Teaching

  • Instruct patient to take medication as directed.
  • May cause dizziness or drowsiness. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.
  • Caution patient to use sunscreen and protective clothing to prevent photosensitivity reactions.
  • Advise patient to avoid taking alcohol or other CNS depressants concurrently with this drug.
  • Advise patient that good oral hygiene, frequent rinsing of mouth with water, and sugarless gum or candy may minimize dry mouth. Patient should notify dentist if dry mouth persists >2 wk.
  • Instruct patient to contact health care professional immediately if dizziness, fainting, or fast or irregular heartbeat occurs or if symptoms persist.

Evaluation/Desired Outcomes

  • Decrease in allergic symptoms.
  • Management of chronic idiopathic urticaria.
  • Management of hives.


A trademark for the drug loratadine.


Allergy medicine A nonsedating sympathomimetic antihistamine containing loratidine and pseudoephedrine, used for seasonal allergies Contraindications MAOI therapy, narrow-angle glaucoma, urinary retention, HTN, CAD. See Antihistamine.
References in periodicals archive ?
Lanier said he expects that Claritin ready tabs and other allergy medications for children will stay in prescription form--at least for now, because the OTC decision only applies to adult Claritin, not pediatric Claritin.
Schering-Plough had hoped to extend its exclusive hold over Claritin to 2004 and beyond because of a related patent on a chemical cousin of Claritin, the Clarinex patent.
There are no approved claims for its comparability with other antihistamines, including Claritin, and in announcing the product's approval, the company did not make any claims about its superiority.
In the United States, the cheapest online pharmacies sell Claritin for more than $2 a pill; local drugstores charge more.
The company recently eliminated Claritin and Allegra from its list of recommended drugs.
Schering-Plough's patent on Claritin (loratadine) expires in December, and the company voluntarily petitioned the FDA for approval to sell all three current formulations--tablets, Redi-tabs, and syrup--over the counter (OTC) for the relief of allergic rhinitis and chronic idiopathic urticaria.
Following Schering-Plough maneuvers that won two separate patent extensions on the drug, the Claritin patent is now set to run out in the year 2002.
New CLARITIN 12-Hour offers the proven allergy relief people have relied on for years, with the added flexibility for people who want more control of their treatment," said Dr.
Schering-Plough posed the argument about a year ago that an over-the- counter version of its Claritin drug could be dangerous for patients.
He found that Allegra and Claritin could increase revenues by 4 percent to 14 percent if they followed the same detailing pattern as Zyrtec -- which had more front loading of advertising expenditures.
11 /PRNewswire-FirstCall/ -- Schering-Plough Corporation today announced the launch of CLARITIN Eye, an antihistamine eye drop strong enough to control itchy eyes all day or all night.