Clara cell

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Cla·ra cell

(klahr'ah),
a rounded, club-shaped, nonciliated cell protruding between ciliated cells in bronchiolar epithelium; believed to be secretory in function.

Clara cell

A cuboidal epithelial cell found in the lining of the terminal and the respiratory bronchioles of the lungs. Clara cells are nonciliated, and they secrete surfactant, like the type II alveolar epithelial cells found deeper in the bronchial tree.
See also: cell

Clara cell

(klăr′ă, klah′ră)
[Max Clara, Austrian anatomist, 1899–1937]
One of the secreting cells in the surface epithelium of the bronchioles. These cells, along with goblet cells, provide secretions for the respiratory tract. The secretion is a mucus-poor protein that coats the epithelium.

Clara,

Max, Austrian anatomist, 1899–.
Clara cell - a rounded, club-shaped, nonciliated cell protruding between ciliated cells in bronchiolar epithelium; believed to be secretory in function. Synonym(s): bronchiolar exocrine cell
Clara hematoxylin

Clara cell

nonciliated, secretory bronchiolar epithelial cells; function as stem cells for repair in the bronchioles and can divide into ciliated or nonciliated bronchiolar cells.
References in periodicals archive ?
In general, mucin expression is more abundant in proximal airways and CCSP expression is more abundant in distal airways, corresponding to the differential abundance of mucous cells and Clara cells, respectively, in these airway regions.
In experimental animals, injury models have shown that rapid bronchiolar repair can be mediated by different cell types, including naphthalene-resistant Clara cells (nonciliated, columnar secretory cells that can act as facultative airway progenitors), bronchioloalveolar stem cells that can maintain both Clara cells and alveolar pneumocytes, and also differentiated ciliated cells.
Dr Whitsett and his team at Cincinnatti Children's team Hospital found "good" lung cells called Clara cells change into mucus cells in a process called metaplasia - and that the process could be reversed.
Mucinous type is composed of mucous (goblet) cells, while nonmucinous type has clara cells and type II cells.
In a second set of experiments, Clara cells were coexposed to Cd at different concentrations (up to 50 [micro]M final) and to 750 [micro]M 2-AF (or 4-ABP) in culture medium.
Clara cells are nonciliated bronchiolar cells and are the principal epithelial cells in the distal airway, whose products include Clara cell secretory protein and some components of surfactant.
Bronchiolar epithelium cells known as Clara cells are thought to help defend airways against damage; Clara cell protein (CC16) is a lung-specific protein thought to protect the respiratory tract from inflammation.
A possible relation between such damage to Clara cells and pulmonary morbidity (e.
We investigated the function of Clara cells in vivo during exposure to inhaled crystalline silica by examining pulmonary matrix metalloproteinase (MMP)-2 and MMP-9 mRNA levels in mice.
Because CC16 is synthesized and secreted almost exclusively by the lung Clara cells, its elevation in serum can be explained only by assuming an increased intravascular leakage of the protein across the lung epithelial barrier (5-7,16).