CLCN3

(redirected from ClC-3)

CLCN3

A gene on chromosome 4q33 that encodes a voltage-gated chloride channel that mediates exchange of chloride ions for protons, acting as as antiporter and contributing to acidification of endosomal and synaptic vesicle lumina; it thus may affect vesicle trafficking and exocytosis. CLCN3 may play a role in neuronal cell function by regulating membrane excitability by protein kinase C, and may have a role in short-term memory.
References in periodicals archive ?
Lead researchers Deborah Nelson and Louis Philipson showed that mice lacking the ClC-3 channel, a passageway that allows negatively-charged chloride ions to pass through cell membranes, have only one-fifth the circulating insulin of normal mice.
A team lead by Ludmila Deriy, a research assistant professor in Nelson's laboratory, studied genetic knockout mice missing the ClC-3 chloride channel.
Missing ClC-3 therefore appears to cause a dramatic slowdown of the conversion of proinsulin to insulin.