Civatte bodies

Ci·vat·te bod·ies

(sē-vaht'),
eosinophilic hyaline spheric bodies seen in the epidermis, in lichen planus and other skin disorders; formed by apoptosis of individual basal cells.
Synonym(s): colloid bodies

Civatte,

Achille, French dermatologist, 1877-1956.
Civatte bodies - eosinophilic hyaline spherical bodies seen in or just beneath the epidermis, particularly in lichen planus, formed by necrosis of individual basal cells. Synonym(s): colloid bodies
Civatte disease - Synonym(s): poikiloderma of Civatte
poikiloderma of Civatte - reticulated pigmentation and telangiectasia of the sides of the cheeks and neck; common in middle-aged women. Synonym(s): Civatte disease
References in periodicals archive ?
Resultant dyskeratosis is represented by the presence of necrotic keratinocytes (Civatte bodies or cytoid bodies), which are extruded into the papillary dermis.
LP pigmentosus showed saw-toothed rete ridges/ irregular acanthosis, vacuolar degeneration of the basal layer, band-like infiltrate, melanophages in upper dermis, Civatte bodies, pigment incontinence, chronic inflammatory infiltrate and perivascular infiltrate.
Civatte bodies, acanthosis, and parakeratosis are the results of lymphocytic infiltration of subepithelial tissue, basal membrane impairment, and degenerations of keratinocytes [1].
The WHO criteria (1978) for histopathological diagnosis of OLP include thickened ortho- or parakeratinised epithelium, liquefaction degeneration of basal layer, well-defined juxtaepithelial lymphocytic infiltration, and Civatte bodies in basal epithelium and lamina propria [3].
Seven years after her initial presentation, deep esophageal biopsy specimens were obtained showing severe acute and chronic esophagitis with a lichenoid-like pattern of chronic inflammation with notable features of lymphocytic infiltrate involving the basal layer of the epithelium and scattered apoptotic keratinocytes (Civatte bodies) (Figures 4 and 5) raising strong consideration of ELP.
Findings that help support a diagnosis of ELP include a band-like lymphocytic infiltrate involving the superficial lamina propria and basal epithelium along with the presence of Civatte bodies [7, 8].
Lichen planus--Generalised with Koebner's phenomenon, histopathology showing basal degeneration and civatte bodies.
In epidermis out of 50 cases, Parakeratosis was seen in 2 cases, Hyperkeratosis in 45 cases, Acanthosis in 42 cases, Spongiosis in 40 cases, Papillomatosis in 10 cases, Saw-toothed rete ridges in 20 cases, Civatte bodies in 46 cases, Liquefactive degeneration of basal layer in 48 cases, and Max-Joseph's space was seen in 6 cases.
Microscopically, the specimen exhibited ortho- keratosis with prominent granular layer, intense band-like lymphohistiocytic infiltrate with plasma cell predominance and hydropic degeneration of basal cell layer with scattered Civatte bodies.
Out of 77 cases of classic LP all patients (100%) had hyperkeratosis (Figure 6) and hypergranulosis in 74 (96%) whereas acanthosis was seen in 71 (92%) cases, elongated rete ridges in 52 (67%) cases, basal cell degeneration in all the cases (90%), band-like inflammatory infiltrate (Figure 7) in 73 (95%) cases, melanin incontinence seen in 76 (98.7%), Civatte bodies seen in 72 (93%) and Max-Joseph spaces in 23 (29.8%) cases.
Immunohistochemical studies on colloid bodies (civatte bodies) in oral lesions of discoid lupus erythematosus.
Necrotic keratinocytes (Civatte bodies) were seen in 17 cases (25.75%) and melanophages in papillary dermis were seen in 16 cases (24.24%).