Resultant dyskeratosis is represented by the presence of necrotic keratinocytes (Civatte bodies or cytoid bodies), which are extruded into the papillary dermis.
LP pigmentosus showed saw-toothed rete ridges/ irregular acanthosis, vacuolar degeneration of the basal layer, band-like infiltrate, melanophages in upper dermis, Civatte bodies, pigment incontinence, chronic inflammatory infiltrate and perivascular infiltrate.
, acanthosis, and parakeratosis are the results of lymphocytic infiltration of subepithelial tissue, basal membrane impairment, and degenerations of keratinocytes .
The WHO criteria (1978) for histopathological diagnosis of OLP include thickened ortho- or parakeratinised epithelium, liquefaction degeneration of basal layer, well-defined juxtaepithelial lymphocytic infiltration, and Civatte bodies
in basal epithelium and lamina propria .
Seven years after her initial presentation, deep esophageal biopsy specimens were obtained showing severe acute and chronic esophagitis with a lichenoid-like pattern of chronic inflammation with notable features of lymphocytic infiltrate involving the basal layer of the epithelium and scattered apoptotic keratinocytes (Civatte bodies) (Figures 4 and 5) raising strong consideration of ELP.
Findings that help support a diagnosis of ELP include a band-like lymphocytic infiltrate involving the superficial lamina propria and basal epithelium along with the presence of Civatte bodies [7, 8].
Lichen planus--Generalised with Koebner's phenomenon, histopathology showing basal degeneration and civatte bodies.
In epidermis out of 50 cases, Parakeratosis was seen in 2 cases, Hyperkeratosis in 45 cases, Acanthosis in 42 cases, Spongiosis in 40 cases, Papillomatosis in 10 cases, Saw-toothed rete ridges in 20 cases, Civatte bodies in 46 cases, Liquefactive degeneration of basal layer in 48 cases, and Max-Joseph's space was seen in 6 cases.
Microscopically, the specimen exhibited ortho- keratosis with prominent granular layer, intense band-like lymphohistiocytic infiltrate with plasma cell predominance and hydropic degeneration of basal cell layer with scattered Civatte bodies
Out of 77 cases of classic LP all patients (100%) had hyperkeratosis (Figure 6) and hypergranulosis in 74 (96%) whereas acanthosis was seen in 71 (92%) cases, elongated rete ridges in 52 (67%) cases, basal cell degeneration in all the cases (90%), band-like inflammatory infiltrate (Figure 7) in 73 (95%) cases, melanin incontinence seen in 76 (98.7%), Civatte bodies
seen in 72 (93%) and Max-Joseph spaces in 23 (29.8%) cases.
Immunohistochemical studies on colloid bodies (civatte bodies
) in oral lesions of discoid lupus erythematosus.
Necrotic keratinocytes (Civatte bodies
) were seen in 17 cases (25.75%) and melanophages in papillary dermis were seen in 16 cases (24.24%).