To investigate, researchers used a mouse model infected with Citrobacter rodentium
, the mouse equivalent of an E.
Experimentally, mice stressed are more likely to have increased susceptibility to coliform intestinal infections (e.g., Citrobacter rodentium
) , which can be reverted by administering Lactobacillus reuteri .
Dangler et al., "Citrobacter rodentium
, the causative agent of transmissible murine colonic hyperplasia, exhibits clonality: synonymy of C.
The following nonpathogenic strains were used for reference experiments: Escherichia coli DH5-Alpha (DH5[+ or -]), enteropathogenic Escherichia coli (EPEC) E2348/69, Citrobacter rodentium
DBS 13 (Citrobacter DBS 13) and Enterobacter cloacae.
First, it can promote host resistance against pathogen by competing for sites of colonization and direct production of inhibition molecules and depletion of nutrients to prevent pathogens expansion and dissemination.[sup], Experiments in germ-free mice demonstrated that gut microbiota plays a role in clearing the pathogenic bacterium Citrobacter rodentium
and the clearance was found to be mediated by the enhanced glycan acquisition capabilities of the transferred bacteria.[sup] Other recent studies revealed that certain gut pathogens, e.g.
However, it has been demonstrated with Citrobacter rodentium
that secretory IgA is not necessary for preventing bacterial colonization in mice using intimin as a vaccine antigen.
They promote the host defense against fungal and bacterial infections, such as Candida albicans, Pseudomonas aeruginosa, Klebsiella pneumonia, Streptococcus pneumonia, and Citrobacter rodentium
(2006) observed that infection with Citrobacter rodentium
induced anxiety-like behaviors via vagal sensory regulation.
Attaching and effacing pathogens include enterohemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC, respectively) and Citrobacter rodentium
Consequences of Citrobacter rodentium
infection on enteroendocrine cells and the enteric nervous system in the mouse colon.
: Crosstalk with the PI3K Pathway
The disruption of gut microbiota that facilitates gut colonization has been demonstrated in murine models infected with Citrobacter rodentium
and Salmonella enterica serovar Typhimurium (13).