citrate synthase

(redirected from Citrate (Si)-synthase)

cit·rate syn·thase

citrate (si)-synthase; an enzyme catalyzing the condensation of oxaloacetate, water, and acetyl-CoA, forming citrate and coenzyme A; an important step in the tricarboxylic acid cycle.


any salt of citric acid. Citrate is the first intermediate of the citric acid cycle and tricarboxylic acid (TCA) cycle. It also plays an important role in fatty acid synthesis which takes place in the cytoplasm. It acts as a carrier of acetyl-CoA, the construction material for fatty acids. The movement is assisted by two enzymes, citrate-condensing enzyme, which catalyzes the condensation of the acetyl unit with oxaloacetate in the mitochondria, and citrate-cleavage enzyme (citrate lyase), which catalyzes the release of the acetyl radical in the cytoplasm of the cell.

citrate cleavage enzyme
important enzyme in fatty acid synthesis from glucose; catalyzes the split of citrate to acetyl CoA and oxaloacetate.
citrate synthase
first enzyme of the TCA cycle catalyzing the formation of citrate from acetyl CoA and oxaloacetate.