SGK3

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SGK3

A gene on chromosome 8q12 that encodes a serine/threonine-protein kinase involved in regulating various ion channels and membrane transporters involved in cell growth, survival and proliferation. It is highly expressed in the pancreas, kidneys, liver, heart and brain.

SGK3 upregulates:
• Na+ channels—e.g., SCNN1A/ENAC and SCN5A;
• K+ channels—e.g., KCNA3/Kv1.3, KCNE1, KCNQ1 and KCNH2/HERG;
• Amino acid transporters—e.g., SLC1A5/ASCT2 and SLC6A19;
• Epithelial Ca2+ channels—e.g., TRPV5 and TRPV6;
• Chloride channel—e.g., BSND
• Creatine transporter—e.g., SLC6A8;
• Glutamate transporter—e.g., SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5;
• Glutamate receptors—e.g., GRIA1/GLUR1 and GRIK2/GLUR6;
• Na+-dependent phosphate cotransporter—e.g., SLC34A2/NAPI-2B;
• Na+/dicarboxylate cotransporter—e.g., SLC13A2/NADC1;
• Na+/H+ exchanger—e.g.,  SLC9A3/NHE3; and
• Na+/K+ ATPase.
References in periodicals archive ?
Simonds Farsons Cisk, one of the Mediterranean's top breweries, is well known to the 750,000 British holidaymakers who visit the island every year.
The celebration was properly sealed 12 hours later at a seaside Maletese bar, with pints of Cisk - another fine local brew - and an expensive bottle of champagne idling in its ice bucket.
Nicola was delighted to discover they were staying at her hotel, and joined them for a few of the local beers, called Cisk, and a gossip - although, sadly, Brad wasn't there!
Then pop into a friendly bar for a local Cisk lager (it costs 40 cents, or about 75p).
Rasmussen, E., 1979: The polar low as an extratropical CISK disturbance.
BRND WGN's clients range from Air Malta, Simonds Farsons Cisk, Bacardi Oakheart to Oulala Fantasy Football.
At night, a glass of Cisk beer, followed by a good meal is as lively as Gozo gets, although an influx of tourists in July and August gees things up a bit.
At night, a glass of local Cisk beer with a cheap meal is as lively as Gozo gets.
At night, a glass of the local Cisk beer, followed by a good meal is about as lively as Gozo gets, although an influx of tourists in July and August tends to gee things up a bit.
A glass of the local Cisk beer, followed by a good meal, is about as lively as it gets, although an influx of Northern Europeans in July and August tends to gee things up a bit.