Cycloviruses, which belong to a proposed new genus in the family Circoviridae, were recently found in serum and cerebrospinal fluid of humans with paraplegia and acute infections of the central nervous system (11,15), suggesting that viruses from the family Circoviridae may have neurologic tropism more commonly than previously anticipated.
Rapidly expanding genetic diversity and host range of the Circoviridae viral family and other Rep encoding small circular ssDNA genomes.
This non-enveloped single-stranded DNA virus was renamed Torque teno virus, a species of the genus Anelloviridae in an unassigned family that is most closely related to Circoviridae
15) The genome of PiCV has been sequenced, (16,17) and, on the basis of similarities in their genomes, PiCV is classified, together with psittacine beak and feather disease virus, porcine circovirus types 1 and 2, goose circovirus, canary circovirus, and duck circovirus, as a member of the genus Circovirus in the family Circoviridae
5], we identified, in decreasing frequency, sequences related to the mammalian viruses: sapovirus (120,177 reads), anelloviridae (14,841 reads), parechovirus (10,557 reads), norovims (4,551 reads), enterovirus (3,857 reads), circoviridae
(2,127 reads), group A rotavirus (839 reads), adeno-associated vims (812 reads), picobimavirus (274 reads), bufavirus (168 reads), WU polyomavirus (136 reads), bocavims (62 reads), adenovims (58 reads), papillomavims (22 reads), cosavirus (20 reads), group C rotavirus (17 reads), human astrovirus 1 (14 reads), salivirus (4 reads), and Aichi virus (2 reads).
Psittacine beak and feather disease virus (family Circoviridae
, genus Circovirus) is a pathogen of clinical importance for which PCR assays have been developed.
Members of the family Circoviridae
are nonenveloped, icosahedral viruses with diameters of 16-26 nm and a small, circular, single-stranded DNA genome (the smallest known autonomously replicating viral genome) (1).
On the basis of genome organization and amino acid sequence identity of Rep proteins, novel circular DNA viruses seem most closely related to others viruses of the family Circoviridae
Comparison with other members of the Circoviridae
demonstrated that RaCV shares the greatest sequence homology with canary circovirus (CaCV) and pigeon circovirus (PiCV) and was more distantly related to the beak and feather disease virus, goose circovirus, duck circovirus, and the 2 porcine circoviruses, PCV1 and PCV2.
Cycloviruses (family Circoviridae
, genus Cyclovirus) have been detected in human and chimpanzee feces and tissues of farm animals, bats, and dragonflies (9-12).
Circoviruses are nonenveloped, spherical viruses with a single-stranded circular DNA genome of [approximately equal to] 2 kb; they group as a genus within the family Circoviridae
, together with the proposed genus Cyclovirus and the phylogenetically more distinct genus Gyrovirus (1).
The characteristics of its genome--a single, closed molecule of circular, negative-sense DNA [approximately equal to] 2,300 nt long--and sequence homology with the chicken anemia virus (CAV) have suggested that HGyV might be the first human-infecting member of the genus Gyrovirus, which is part of the family Circoviridae
and encompasses only 1 previously known species, CAV (2).