Ultimately, we were not able to reach our goal of using siLRP2 as a therapeutic alternative to cilastatin
- China Imipenem and cilastatin
sodium Market, 2010-2019
The treatment was systemic with Tienam (imipenem and cilastatin
) 500 mg i.v., every 12 hours, PDN 30 mg/day (after 7 days 25 mg), Diflucan (fluconazolum) 1 cp/day, Dicarbocalm (calcium carbonate, magnesium carbonate and trisilicate) 1 tbx3/day.
Camano et al., "Cilastatin
protects against cisplatin-induced nephrotoxicity without compromising its anticancer efficiency in rats," Kidney International, vol.
Moreno-Gordaliza et al., "Cilastatin
attenuates cisplatin-induced proximal tubular cell damage," Journal of Pharmacology and Experimental Therapeutics, vol.
Eight hours after sepsis induction, when the animals showed clinical signals of sepsis (ruffled fur, hypothermia, lacrimation, lethargy), a combination of the antibiotics imipenem and cilastatin
(8 mg/kg) was injected subcutaneously to increase the survival rate.
Patient was kept on continuous oxygen inhalation and was immediatly started on intravenous injectible Artesunate therapy at dose of 120 mg 12 hourly (2.4 mg/kg stat followed by 2.4 mg/kg at 12 and 24 h and then daily) along with intravenous injectible Imipenem and Cilastatin
combination (500 mg plus 500 mg) every six hourly through peripheral intravenous line which were given for five continuous days.
The drug discs used were as follows: Penicillin Group: Methicillin (Oxacillin 5ug), Amoxicillin (20ug), Amoxicillin + Clavulanic acid (20/10ug), Piperacillin + Tazobactam (100/10 ug ) , Glycopeptides: Vancomycin (30ug), Teicoplanin (30ug), Carbapenems: Meropenem (10ug), Imipenem + Cilastatin
Sodium (10 ug), Cephalosporins: Cephradine (25ug), Ceftriaxone (30ug), Ceftazidime (30 ug), Cefoperazone (75ug) and Fluoroquinolones: Ciprofloxacin (5ug) and Enoxacin (10ug).
The firm also launched nine new products last year, including Valaciclovir and Imipenem + Cilastatin
. It has completed the upgrading of its plant in South Africa and has received approval from the Medicines Control Council (MCC) for a manufacturing facility in Roodepoort, South Africa.
, given to extend the duration of imipenem, is also eliminated by the kidney.