Schechter, "Quantitation of histamine, tryptase, and chymase
in dispersed human T and TC mast cells," The Journal of Immunology, vol.
Miller, "Release of the mucosal mast cell granule chymase
, rat mast cell protease-II, during anaphylaxis is associated with the rapid development of paracellular permeability to macromolecules in rat jejunum," Journal of Experimental Medicine, vol.
Moreover, Ang II can also be generated by chymase
, and the mRNA for chymase
was not altered in the lung tumor cells.
Xia, "Beneficial effects of astragalus polysaccharides treatment on cardiac chymase
activities and cardiomyopathy in diabetic hamsters," Acta Diabetologica, vol.
Clauson et al., "Proteome analysis of mast cell releasates reveals a role for chymase
in the regulation of coagulation factor XIIIA levels via proteolytic degradation," Journal of Allergy and Clinical Immunology, vol.
(2000) Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase
, mouse mast cell protease-1.
Sippola et al., "Mast cell chymase
degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation," The Journal Biological Chemistry, vol.
Vasoactive mediators (histamine, leukotriene, and serotonin) and proteases (tryptase, chymase
) are released both locally and into the systemic circulation by mast cell degranulation after contact with the allergens that have a role in the etiology .
Many pre-formed mediators are involved in an anaphylactic reaction, including histamine, tryptase, chymase
, mast cell carboxypeptidases, platelet activating factor and others.
When the researchers studied blood serum samples from patients with dengue infection, they found that the levels of a protein produced by mast cells, chymase
, were significantly higher in the patients who developed dengue hemorrhagic fever compared to those who recovered after dengue fever.
Welle, "Development, significance, and heterogeneity of mast cells with particular regard to the mast cell-specific proteases chymase
and tryptase," Journal of Leukocyte Biology, vol.
The measurements of serum specific IgE directed to the [beta]-lactams, serum chymase
and tryptase levels were not performed (due to a lack of laboratory support).