chronic inflammatory demyelinating polyneuropathy


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chron·ic in·flam·ma·to·ry de·my·e·li·nat·ing pol·y·neu·rop·a·thy (CIDP),

an uncommon, acquired, demyelinating sensorimotor polyneuropathy, clinically characterized by insidious onset, slow evolution, (either steady progression or stepwise), and chronic course; symmetric weakness is a predominant symptom, often involving proximal leg muscles, accompanied by paresthesias, but not pain; CSF examination shows elevated protein, whereas electrodiagnostic studies reveal evidence of a demyelinating process, primarily conduction slowing rather than block; sometimes responds to prednisone.

chronic inflammatory demyelinating polyneuropathy

Abbreviation: CIDP
A gradually progressing autoimmune muscle weakness in arms and legs caused by inflammation of the myelin sheath covering peripheral nerve axons. Demyelination slows or blocks conduction of impulses to muscles. Numbness and paresthesia may accompany or precede loss of motor function, which varies from mild to severe. Laboratory findings include elevated protein levels in the cerebrospinal fluid. The inflammatory damage involves not only phagocytes (neutrophils and macrophages), but also immune complexes and complement activation by myelin autoantigens. Immunosuppressive drugs are used to treat this illness. Plasma exchange therapy or infusions of immunoglobulins often are used first, to produce a remission. CIDP is considered to be a chronic counterpart to Guillain-Barré syndrome.
See also: polyneuropathy
References in periodicals archive ?
Table 5 Global Chronic Inflammatory Demyelinating Polyneuropathy Market For Diagnosis By Type,
Table 6 Global Chronic Inflammatory Demyelinating Polyneuropathy Market For Electrodiagnostic Testing
Comparison of electrodiagnostic abnormalities and criteria in a cohort of patients with chronic inflammatory demyelinating polyneuropathy. Arch Neurol.
The spectrum of chronic inflammatory demyelinating polyneuropathy. J Neurol Sci.
A distinct subgroup of chronic inflammatory demyelinating polyneuropathy with CNS demyelination and a favorable response to immunotherapy.
Long term prognosis of chronic inflammatory demyelinating polyneuropathy: A five year follow up of 38 cases.
Plasma-exchange therapy in chronic inflammatory demyelinating polyneuropathy: a double-blind, shamcontrolled, cross-over study.
Dyck et al coined the phrase chronic inflammatory demyelinating polyneuropathy (5) several years after they reported the first case series of 53 patients with this disease complex.
Chronic inflammatory demyelinating polyneuropathy: Clinical features and response to treatment in 67 consecutive patients with and without a monoclonal gammopathy.
Clinicopathologic findings and prognosis of chronic inflammatory demyelinating polyneuropathy. Neurology 1999;52:498-503.
(8.) Research criteria for diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP).

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