balanced translocation

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bal·anced trans·lo·ca·tion

translocation of the long arm of an acrocentric chromosome to another chromosome; an individual with a balanced translocation has a normal diploid genome and is clinically normal but has a chromosome count of 45 and as a result of asymmetric meiosis may have children lacking the genes on the translocated segment or have them in trisomy.

balanced translocation

the transfer of segments between nonhomologous chromosomes in such a way that the configuration and total number of chromosomes change, but each cell contains the normal amount of diploid or haploid genetic material. Usually the long arm of an acrocentric chromosome is transferred to another chromosome, and the small fragment containing the centromere is lost, leaving only 45 chromosomes. A person with a balanced translocation is phenotypically normal but may produce children with trisomies. Compare reciprocal translocation, robertsonian translocation.

bal·anced trans·lo·ca·tion

(bal'ănst tranz-lō-kā'shŭn)
Translocation of the long arm of an acrocentric chromosome to another chromosome; a person with a balanced translocation has a normal diploid genome and is clinically normal but has a chromosome count of 45 and as a result of asymmetric meiosis may have children lacking the genes on the translocated segment or having them in trisomy.
References in periodicals archive ?
The signature molecular abnormality of synovial sarcoma consists of a balanced chromosomal translocation t(X;18)(p11;q11) that results in an in-frame fusion of SS18 to SSX1, SSX2, or in rare instances, SSX4.
Chromosome 10 was frequently involved in chromosomal translocation, which may be catastrophic genomic events and play key roles in tumorigenesis.
Basic semen analysis of the male patient and the fact that he had previously fathered a healthy child indicated that his fertility was not affected by his chromosomal translocation, contrary to previous literature reports stating that male balanced translocations carriers are prone to sterility.
T (1:14) is a very infrequently occurring recurrent chromosomal translocation and has been described to be associated with haematological malignancies.
We know he has what is called a chromosomal translocation - his chromosomes are all there, but they're arranged differently.
It is a variation of AML that frequently exhibits a typical chromosomal translocation.
5) The myxoid variant, which is characterized by the chromosomal translocation t(12;16) (q13;p11), is a lobulated soft-tissue tumor composed of slender, hyperchromatic spindle cells and signet-ringlipoblasts, a plexiform vascular pattern, and a myxoid matrix.
For example, the development of the drug imatinib (Gleevec)-one of the most successful targeted cancer therapies to date-stems directly from Rowley's work on the chromosomal translocation associated with CML.
The chromosomal translocation t(15;17) results in PML/RAR [alpha] fusion gene, t(8;21) results in AML1/ETO fusion gene and Inv 16 generates CBF [beta]/MYH11 fusion gene.
Sequence and analysis of the human ABL gene, the BCR gene and regions involved in the Philadelphia chromosomal translocation.
The chromosomal translocation results in a fusion between RAR [alpha] and another gene whose product is 'PML', generating a fusion product PML-RAR [alpha] , a chimaeric oncoprotein that has been extensively studied over the last 10 years.
Mucosa-associated lymphoid tissue (MALT) lymphoma of the rectum with chromosomal translocation of the t(11;18)(q21;q21) and an additional aberration of trisomy 3.

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