was then passed on to Sarah, something she was tested for as a baby.
Further, if proposed mechanisms for chimeric RNA-templated chromosomal translocation
and activity as ceRNA are found to be true, controlled regulation of chimeric transcripts could play an important role in preventative cancer treatment.
Subsequent studies demonstrated that EBV was a potent growth-transforming agent for primary B-cells, and that all cases of BLs carried characteristic chromosomal translocations
resulting in constitutive activation of the c-MYC oncogene .
Additionally, the MZLs do not carry the hallmark chromosomal translocation
of t(11;14) that is seen in MCL [7,15].
Fluorescent in situ hybridization (FISH) showed typical Burkitt's disease chromosomal translocation
t(14;18) in healthy individuals.
The t(8; 14) chromosomal translocation
occurring in B-cell malignancies results from mistakes in V-D-J joining.
One prominent and unifying factor is the t(X;18)(p11;q11) chromosomal translocation
, which is unique to synovial sarcoma and is identified in more than 95% of all cases.
A 28-year-old man with history of chromosomal translocation
13/14 and no prior liver disease presented to the hospital with complaint of fevers, nonbloody emesis, and dark urine.
Conclusions: The lung adenocarcinoma cell line OM exhibited multiple complex karyotypes, and chromosome 10 was frequently involved in chromosomal translocation
, which may play key roles in tumorigenesis.
It proves that phenotypically normal embryos originating from a chromosomal translocation
carrier may be carrying chromosomal imbalances.
In 95% of cases, the cause of DS is chromosomal aneuploidy, Trisomy 21, but rare cases of DS can arise from either chromosomal translocation
or from mosaicism.