Geraedts, "Intra- and inter-observer variation in the interpretation of histological features suggesting
chromosomal abnormality in early abortion specimens," Histopathology, vol.
PRECIS: The ideal approach to pregnancies with a
chromosomal abnormality should be tailored according to the individual choice of the couples regarding whether they decide for or against a child with a known
chromosomal abnormalityA woman of any age can have a fetus with trisomy or another
chromosomal abnormality, and some women prefer diagnostic testing or no testing regardless of age.
The most common
chromosomal abnormality detected in this study was Down's syndrome, which was similar to the result shown by other workers.
Between 50 and 80 percent of embryos created for in vitro fertilization have a
chromosomal abnormality and result in miscarriage, rather than developing into a pregnancy.
This process allows the reproductive endocrinologist to select only chromosomally healthy embryos for replacement with the aim of increasing the chance of successful implantation, reducing spontaneous abortion, minimising the chance for a fetus to have a
chromosomal abnormality and enhancing delivery rates for assisted reproduction.
There was no
chromosomal abnormality in this group, except one fetus with mosaicism of Turner syndrome (45,X[15]/46,XX[35]), and this child was doing well at the age of 4 years.
A little extension will come as a boon to a lot of women." Out of the 26 million births that occur in India every year, approximately 2- 3 per cent foetuses have a severe congenital or
chromosomal abnormality.
The nuchal translucency (NT), which is the fluid behind the foetal neck, is measured between 11-14 weeks to determine the risk of the foetus having not only a
chromosomal abnormality, but also cardiac, other structural abnormality in the foetus, or a genetic disorder.
Reciprocal translocation is the most common
chromosomal abnormality found in 1 in 500 people (11).
Newcastle University researchers have discovered a link between a rare
chromosomal abnormality and a form of childhood leukaemia.
At age 35, the chance of having a baby with Down syndrome is 1 in 380, but the chance of having any
chromosomal abnormality detectable by karyotype is 1 in 190.
