is a 439-residue-long glycoprotein [15,16], a member of a larger family of soluble secretory proteins (granin proteins) that includes also chromogranin B (CgB), secretogranin (Sg) II (CgC), Sg III (1B1075), Sg IV (HISL-19), Sg V (7B2) and Sg VI (NESP55), Sg VII (VGF), and Sg VIII (proSAAS) , localized in secretory granules of neuroendocrine cells, neurons, and the adrenal medulla .
The authors want to thank Novartis Pharma AG for their support in providing Chromogranin A
assay kits throughout the study.
Diagnosis can be made by the clinical picture and supported by imaging, endoscopy, or tumor markers such as chromogranin A
Using the range established by the EDI Chromogranin A
ELISA Kit, the patients were divided into three groups based on baseline CgA levels: normal CgA (<120 ug/ml), under 3 time normal (360 ug/ml).
Carcinoid tumours secrete a variety of tumour markers, including 5HIAA, Chromogranin A
, cytokeratins, CD56 and Ki67.
7 August 2014 - A study, carried out by Chinese researchers and published today in BMC Endocrine Disorders, has demonstrated that Chromogranin A
(CgA) is a reliable serum diagnostic biomarker for pancreatic neuroendocrine tumours (PNETs) but not for insulinomas.
The clinical relevance of chromogranin A
as a biomarker for gastroentero-pancreatic neuroendocrine tumors.
Immunohistochemical studies were positive for synaptophysin and CD56 (NCAM), chromogranin A
, epithelial antigen, and CAM 5.2/AE-1.
The cases were stained for TTF-1, EMA, low-molecular-weight cytokeratin (CAM 5.2), endothelial cell marker (CD31), surfactant protein B (PE10), and chromogranin A
. Immunohistochemical studies were performed on formalin-fixed, paraffin-embedded tissue sections.
The tests recommended by the report include DOTA-Octreotide scan, Upper and Lower GI endoscopies with biopsies (if required), repeat Chromogranin A
and B levels for comparison, serum catecholamine/meanphrine levels, 24 hours urinary VMA and Catecholamnine levels and MR scan for spine.
Products to note from this catalog include Euro Diagnostica's gold standard anti-CCP ELISA, ANCA ELISA, Pertusscan ELISA, Complement, as well as endocrine and tumor markers including Chromogranin A
and B assays.
Human chromogranin A
(CgA), a member of the granin family, is an acidic 439-amino acid protein with a widespread expression in endocrine cells and neurons (1-3).