chromogranin A


Also found in: Acronyms, Wikipedia.

chromogranin A

A major protein in catecholamine storage vesicles (chromaffin granules) of the adrenal medulla, which is co-released therefrom with catecholamines by exocytosis.
 
Abnormal expression
Increased in anterior pituitary adenoma, parathyroid carcinoma, medullary thyroid carcinoma, carcinoid tumour, pancreatic islet cell tumour, small cell lung carcinoma.

Ref range
10–50 ng/mL.

chromogranin A

see parathyroid secretory protein.
References in periodicals archive ?
Molecular cloning and primary structure of human chromogranin A (secretory protein I) cDNA.
Chromogranin A processing and secretion: specific role of endogenous and exogenous prohormone convertases in the regulated secretory pathway.
Chromogranin A levels have been correlated with survival and prognosis in patients with metastatic gut neuroendocrine tumors.
Plasma chromogranin A as marker for survival in patients with metastatic endocrine gastroenteropancreatic tumors.
We are pleased to see the consistent clinical results yielded by the EDI Chromogranin A ELISA Kit in this study.
We are happy that our chromogranin A kit played a role in the establishment of these results.
7 August 2014 - A study, carried out by Chinese researchers and published today in BMC Endocrine Disorders, has demonstrated that Chromogranin A (CgA) is a reliable serum diagnostic biomarker for pancreatic neuroendocrine tumours (PNETs) but not for insulinomas.
The clinical relevance of chromogranin A as a biomarker for gastroentero-pancreatic neuroendocrine tumors.
Measurements of chromogranin B can serve as a complement to chromogranin A.
Immunohistochemical findings included positive staining with synaptophysin and CD56 (NCAM) and weak staining with chromogranin A and CAM 5.
To evaluate the chromatographic separation of labeled and nonlabeled peptides, 1 mL of the monoiodinated peak fraction was mixed with 10 pmol of the relevant synthetic tyrosine-extended chromogranin A fragment and reapplied to the HPLC column as described.
Secretion of chromogranin A by peptide producing endocrine neoplasms.