CHRD

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CHRD

A gene on chromosome 3q27 that encodes chordin, a secreted protein that dorsalises early vertebrate embryonic tissues by binding to ventralising TGF-beta-like bone morphogenetic proteins (BMPs), sequestering them in latent complexes, and may be involved in organogenesis.
References in periodicals archive ?
Based on the number of ring cysteine domains, they are classified as: (a) 8-ring cysteine proteins, members of DAN (7,8); (b) 9-ring cysteine proteins, twisted gastrulation (tgs) (9,10); and (c) 10-ring cysteine proteins, Chordin (Chd) and Noggin (Nog) (11-14).
4E) probably through the action of Chordin, which is an antagonist for Admp and Bmp2/4 and is expressed in the dorsal region of the epidermis.
Total RNA of the somites was extracted and RT-PCR carried out with specific primers of cerberus, chordin, FGF8, follistatin and noggin.
The ectopic expression of shh or bmp2b in the blastema induced excess bone deposition and altered the patterning of the regenerate; and the forced expression of the Bmp antagonist Chordin disrupted fin growth and osteoblast differentiation (Smith et al, 2006).
Vertebrates develop a corresponding dorsal-ventral gradient with bone morphogentic protein (BMP, homologous to DPP) and chordin (homologous to SOG).
Differential regulation of the bone morphogenic protein antagonist chordin in human normal and osteoarthritic chondrocytes.
Genomic organisation of the human chordin gene and mutation screening of candidate Cornelia de Lange syndrome genes.
More recent studies have shown that genes such as noggin, follistatin, chordin, cerberus, and xnr3 may be involved in neural induction.
2, 1994 Cell, De Robertis and his colleagues reported isolating a gene called chordin.
Asymmetric expression of the bmp antagonists chordin and gremlin in the sea anemone Nematostella vectensis: implications for the evolution of axial patterning.
Asymmetric expression of the BMP antagonists chordin and gremlin in the sea anemone Nemtitustella vectensis: implications for the evolution of axial patterning.
Components identified from the arrayed clones of the EST collection include bmp2/4, bmp5-8, twg, cv-2, xolloid/tolloid, chordin, noggin, follistatin, gremlin1, gremlin2, neuralin, dan, kielin-like, bmpR1B, bmpR2, bambi, smad1/5, smad4, smad6/7, smurf, and tak.