Choragon

Choragon

A brand name for CHORIONIC GONADOTROPHIN.
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The commercial hCG preparations Sigma C6322 (CHO-cell recombinant hCG) and C5297 (Sigma Diagnostics), Serono Profasi (Serono), Ferring Choragon (Ferring), Organon Pregnyl (Organon), and Scripps C0713 and C0714 (Scripps Laboratories) were purchased or provided as gifts (all but the Sigma preparations) and analyzed similarly in specific immunoassays to determine the content of intact hCG and hCG-related molecules.
These range from Sigma C6322, which is free of all hCG structural variants (Table 3); to Scripps C0713, which is rich in nicked hCG (15% of total immunoreactivity), hCGb (5%), and urine hCGbcf (16%); to Ferring Choragon; Organon Pregnyl; and Sigma C5297, which are all rich in nicked hCG (12-14% of total immunoreactivity), hCGb (5-14%), and particularly rich in urinary hCGbcf (39-52%).
Contaminant, (b) % Intact Hyperglycosylated Nicked Preparation (a) hCG, % hCG hCG Sigma C6322 100 <0.9 (19) <0.1 Serono Profasi 98 6 ND (d) Scripps C0714 98 ND 14 Scripps C0713 79 ND 15 Ferring Choragon 68 4 12 Organon Pregnyl 38 7 10 Sigma C5297 34 ND 14 Contaminant, (b) % Calibration with Preparation (a) hCGb hCGa hCGbcf 3rd IS, (c) IU/mg Sigma C6322 <0.1 <0.1 <0.1 11 900 Serono Profasi 1.6 ND 0.6 10 000 Scripps C0714 0.8 ND 0.8 11 000 Scripps C0713 5 ND 16 9000 Ferring Choragon 5 ND 39 ~5000 Organon Pregnyl 12 ND 40 3000 Sigma C5297 14 ND 52 3000 (a) Products are sorted in order of descending proportions of intact hCG.