chondroid syringoma


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chon·droid sy·rin·go·ma

a benign tumor of sweat glands with a mucoid stroma showing cartilaginous metaplasia.
Synonym(s): mixed tumor of skin

chondroid syringoma

An uncommon, benign, 0.5- to 3.0-cm skin tumour of the head and neck which affects patients above age 40, and recapitulates the histologic features of mixed tumour of the salivary gland.
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The main differential diagnosis is chondroid syringoma, which is also known as a benign mixed tumor of the skin, and comprises of bland tumor cell nodules surrounded by a hyaline myxoid stroma commonly admixed with calcifications as well as ossifications.
The incidence of chondroid syringoma is less than 0.01% of all primary skin tumors.4 They usually present as slow growing, painless, solid, subcutaneous or intradermal nodules with a normal margin.
Chondroid syringoma mixed tumour of skin most often occurs as solitary slowly growing nodule.
Tumors Age groups (in years) 1-10 11-20 21-30 31-40 Sweat gland tumors 1 Chondroid syringoma 1 1 2 Eccrine poroma 1 1 3 Nodular hidradenoma 2 2 4 Apocrine hidrocystoma 5 Syringocystadenoma papilliferum 1 1 sebaceous gland tumors 6 Sebaceous adenoma 7 Sebaceous carcinoma Hair follicle tumors 8 Trichoepithelioma 1 1 9 Trichofolliculoma (Sebaceous) 1 1 10 Pilomatricoma 1 2 2 4 11 Proliferating trichilemmal cyst 1 Total 3 6 6 9 Sr.
Chondroid syringoma: case report and review of the literature.
A chondroid syringoma is a rare mixed tumor of sweat-gland origin that has both a benign and malignant form.
(57) Mixed tumor of skin is morphologically identical to pleomorphic adenoma of the salivary gland, exhibiting secondary structures such as glands/ducts, cysts, keratinous cysts, and foci of squamous differentiation, with a mucoid stroma typically showing cartilaginous metaplasia (hence also known as chondroid syringoma).
Nodular Hidradenoma 5 Malignant 1 chondroid syringoma 2.
Mixed tumors of the salivary gland (pleomorphic adenoma) and sweat gland origin (chondroid syringoma).
Auricular ossification has also been associated with inflammatory conditions such as chondritis, perichondritis, and syphilitic perichondritis, as well as with neoplasms such as nevi of the face, pilomatrixoma, and chondroid syringoma. (4) Finally, many systemic diseases can lead to auricular ossification, including congenital plaque-like osteomatosis, Albright hereditary osteodystrophy, fibrodysplasia ossificans progressiva, Addison disease, osseous heteroplasia, and collagen vascular diseases, especially CREST syndrome and childhood dermatomyositis.
Chondroid syringoma of the skin is nearly identical to PA morphologically, and PLAG1 expression can be detected by IHC; while some authors (10) have reported PLAG1 gene rearrangements, this has not been the case in all series.