choline acetyltransferase

(redirected from Choline Acetyl Transferase)
Also found in: Encyclopedia.

choline

 [ko´lēn]
an amine that occurs in phosphatidylcholine and acetylcholine, and is an important methyl donor in intermediary metabolism. Choline is a lipotropic agent, a substance that decreases liver fat content by increasing phospholipid turnover. It was formerly considered to be a B vitamin and is now classified as a pseudovitamin, although it is still sometimes classified as part of the vitamin B complex. Vitamin B12 and folacin are involved in the synthesis of choline.
choline acetylase (choline acetyltransferase) an enzyme that brings about the synthesis of acetylcholine.
choline magnesium trisalicylate see under trisalicylate.
choline salicylate see salicylate.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

cho·line a·ce·tyl·trans·fer·ase

[MIM*118490]
an enzyme catalyzing the condensation of choline and acetyl-coenzyme A, forming O-acetylcholine and coenzyme A.
Synonym(s): choline acetylase
Farlex Partner Medical Dictionary © Farlex 2012

choline acetyltransferase

An enzyme encoded by CHAT on chromosome 10q11.2 that binds acetylCoA to choline, controlling acetylcholine production at the synapses of autonomic nervous system, muscle and the sympathetic nervous system.

Molecular pathology
Polymorphisms of CHAT have been associated with choline acetyltransferase depletion in Alzheimer’s disease and cognitive impairment. CHAT mutations are associated with congenital myasthenic syndrome with episodic apnoea.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

choline acetyltransferase

Choline acetylase An enzyme which controls acetylcholine production in synapses of the autonomic nervous system, muscle, and SNS, which may be depleted in Alzheimer's disease
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

cho·line a·ce·tyl·trans·fer·ase

(kō'lēn ăs'e-til-trans'fĕr-ās)
An enzyme catalyzing the condensation of choline and acetyl-coenzyme A, forming O-acetylcholine and coenzyme A.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
It is necessary to further the development of a radioactive imaging agent for choline transporter (ChT) and choline acetyl transferase (ChAT).
ChAT: choline acetyl transferase; VAChT: acetylcholine transporter; AChR: acetylcholine receptor; AChE: acetylcholine esterase; ChT: choline transporter.