Chloroquine-Resistant Malaria

P falciparum which is resistant to chloroquine—a pharmacologic ‘staple’ used to treat and as prophylaxis for visitors to malaria endemic regions of Africa
Mechanism of resistance Resistant strains of P falciparum do not concentrate chloroquine; resistance is reversed by verapamil, a calcium channel blocker
References in periodicals archive ?
The operation, dubbed Project 523 for the day it was announced - May 23, 1967 - set out to battle chloroquine-resistant malaria.
Chloroquine-resistant malaria is found in parts of Namibia although prevalence can vary at different times of the year.
Menhadenfish oil in a vitamin E-deficient diet: protection against chloroquine-resistant malaria in mice.
Unfortunately, chloroquine-resistant malaria is common throughout Africa, so bowhunters heading there must choose from three alternatives.
DNDi's initial drug development efforts are aimed at chloroquine-resistant malaria, human African trypanosomiasis (sleeping sickness), visceral leishmaniasis (also called kala-azar), and Chagas disease.
Because of the danger of traveling to areas where chloroquine-resistant malaria is endemic, pregnant women should think twice before traveling to such areas as east Africa and Thailand.
The MSS-HTA was compared with a standard allele-restricted PCR (ARPCR) in clinical samples from Malawi, a country where standard PCR analyses and a recent clinical trial have suggested that chloroquine-resistant malaria has disappeared (6-9).
He also directs a project in Malawi, Africa where his team discovered that chloroquine-resistant malaria disappeared after several years of stopping use of the drug.
In the in-vitro studies, HE2000 was compared to chloroquine in treating red blood cells (RBCs) infected with chloroquine-sensitive malaria and with chloroquine-resistant malaria.
Jackson Foundation for the Advancement of Military Medicine on behalf of the Naval Medical Center, San Diego, Infectious Disease Division, to evaluate a new investigational drug candidate as a potential treatment for malaria and for chloroquine-resistant malaria.
The clinical investigators' comprehensive analysis of the results of the first study -- a randomized, double-blind trial in 560 Vietnamese adults with severe Plasmodium falciparum malaria -- suggested that artemether is at least as effective as quinine in the treatment of severe chloroquine-resistant malaria.