P falciparum which is resistant to chloroquine—a pharmacologic ‘staple’ used to treat and as prophylaxis for visitors to malaria endemic regions of Africa Mechanism of resistance Resistant strains of P falciparum do not concentrate chloroquine; resistance is reversed by verapamil, a calcium channel blocker
DNDi's initial drug development efforts are aimed at chloroquine-resistant malaria, human African trypanosomiasis (sleeping sickness), visceral leishmaniasis (also called kala-azar), and Chagas disease.
The MSS-HTA was compared with a standard allele-restricted PCR (ARPCR) in clinical samples from Malawi, a country where standard PCR analyses and a recent clinical trial have suggested that chloroquine-resistant malaria has disappeared (6-9).
Jackson Foundation for the Advancement of Military Medicine on behalf of the Naval Medical Center, San Diego, Infectious Disease Division, to evaluate a new investigational drug candidate as a potential treatment for malaria and for chloroquine-resistant malaria.
The clinical investigators' comprehensive analysis of the results of the first study -- a randomized, double-blind trial in 560 Vietnamese adults with severe Plasmodium falciparum malaria -- suggested that artemether is at least as effective as quinine in the treatment of severe chloroquine-resistant malaria.