Chloroquine-Resistant Malaria

P falciparum which is resistant to chloroquine—a pharmacologic ‘staple’ used to treat and as prophylaxis for visitors to malaria endemic regions of Africa
Mechanism of resistance Resistant strains of P falciparum do not concentrate chloroquine; resistance is reversed by verapamil, a calcium channel blocker
References in periodicals archive ?
Drugs for chloroquine-resistant malaria are quinine, sulfadoxine-pyrimethamine combination, mefloquine, artesunate and its derivatives, halfantrine and certain antibiotics.
Terms related to drug resistance, Number gene mutations, or countries of occurrences Cluster # 1 (red) = 138 items Chloroquine resistance transporter 20 Chloroquine-resistant 15 Chloroquine-resistant malaria 21 Chloroquine-resistant P.
Chloroquine-resistant malaria in travelers returning from Haiti after 2010 earthquake.
There is no role for chloroquine because chloroquine-resistant malaria is present in this country.
Chloroquine-resistant malaria is found in parts of Namibia although prevalence can vary at different times of the year.
Update on hypothesis linking chloroquine-resistant malaria to disease-causing HIV.
For example, chloroquine-resistant malaria is widespread in sub-Saharan Africa, including Nigeria, and resistance to sulfadoxine-pyrimethamine also occurs in this region.
Unfortunately, chloroquine-resistant malaria is common throughout Africa, so bowhunters heading there must choose from three alternatives.
DNDi's initial drug development efforts are aimed at chloroquine-resistant malaria, human African trypanosomiasis (sleeping sickness), visceral leishmaniasis (also called kala-azar), and Chagas disease.
Because of the danger of traveling to areas where chloroquine-resistant malaria is endemic, pregnant women should think twice before traveling to such areas as east Africa and Thailand.
Kirk, "A verapamil-sensitive chloroquine-associated [H.sup.+] leak from the digestive vacuole in chloroquine-resistant malaria parasites," Journal of Cell Science, vol.
Since 1990, CDC has recommended mefloquine as antimalarial prophylaxis in regions with chloroquine-resistant malaria; doxycycline has been the recommended alternative [4].