chloramphenicol

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chloramphenicol

 [klor″am-fen´ĭ-kol]
a broad-spectrum antibiotic with specific therapeutic activity against rickettsiae and many different bacteria. Side effects include serious, even fatal, blood dyscrasias in certain patients. Frequent blood tests are recommended during therapy.

chlor·am·phen·i·col

(klōr'am-fen'i-kol),
An antibiotic originally obtained from Streptomyces venezuelae. It is effective against several pathogenic microorganisms. A serious reaction resulting in marrow damage with agranulocytosis or aplastic anemia may occur. Gray syndrome may occur in newborns because glucuronosyltransferase, needed to metabolize the drug, is lacking.

chloramphenicol

(klôr′ăm-fĕn′ĭ-kôl′, -kŏl′, -kōl′)
n.
A broad-spectrum antibiotic, C11H12Cl2N2O5, derived from the soil bacterium Streptomyces venezuelae or produced synthetically.

chloramphenicol

Infectious disease A broad-spectrum antibiotic effective against gram-positive cocci–eg Staphylococcus aureus and gram-negative coccobacilli–eg Brucella abortus Complications Aplastic anemia

chlor·am·phen·i·col

(klōr'am-fen'i-kol)
An antibiotic originally obtained from Streptomyces venezuelae. It is effective against various pathogenic microorganisms, including Staphylococcus aureus, Brucella abortus, Friedländer bacillus, and the organisms of typhoid, typhus,and Rocky Mountain spotted fever; active by mouth. A serious reaction resulting in marrow damage with agranulocytosis or aplastic anemia may occur.

chloramphenicol

An antibiotic originally derived from the soil bacterium Streptomyces venezuelae . It is highly effective in many serious conditions but has some dangerous side effects which limit its use mainly to external eye infections. In view of the spread of antibiotic-resistant organisms, however, systemic chloramphenicol is again being used to treat dangerous infections. The drug is on the WHO official list. Brand names of the eye preparations are Chloromycetin, Kemicetin, Minims chloramphenicol and Sno Phenicol.

chloramphenicol

a BACTERIOSTATIC antibiotic produced by a species of Streptomyces that interferes with protein synthesis on the 50S subunit of the RIBOSOME of prokaryotes. Chloramphenicol inhibits the activity of the enzyme peptidyl transferase which catalyses the formation of peptide bonds between amino acids as they are added to the polypeptide chain.

chloramphenicol 

A broad-spectrum antibiotic effective against a wide variety of Gram-negative and Gram-positive bacteria (but not Pseudomonas aeruginosa). It is commonly used in solution 0.5% or ointment 1% to treat bacterial conjunctivitis or blepharitis.

chlor·am·phen·i·col

(klōr'am-fen'i-kol)
An antibiotic effective against several pathogenic microorganisms.