Chlordecone

A carcinogenic chlorinated polycyclic ketone insecticide and fungicide used in the US between 1966 and 1975. It gained notoriety from its improper handling and dumping into the James River, Virginia, which was subsequently closed to fishing. Chlordecone has a 30-year environmental half-life
Toxicity Tremors, nystagmus, memory loss, headaches, slurred speech, unsteadiness, incoordination, loss of weight, rash, hepatomegaly, decreased libido, sterility, chest pain, arthralgia, and the increased risk of cancer
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population were excluded from evidence summaries: studies of chlordecone exposure in Guadeloupe (Boucher et al.
Guzelian, "Comparative toxicology of chlordecone (kepone) in humans and experimental animals," Annual Review of Pharmacology and Toxicology, vol.
Idiopathic rICP has been reported in several studies and also as a complication of a list of drugs, including chlordecone (kepone), ketoprofen or indomethacin in Bartter's syndrome, thyroid replacement therapy in hypothyroid children, tetracycline and its derivatives, amiodarone, hypervitaminosis A, lithium carbonate, nalidixic acid, sulfa antibiotics and risperidone.
L'impact de l'utilisation des pesticides sur l'augmentation des cas de cancers a ete particulierement mis en evidence avec l'utilisation du chlordecone dans les Antilles durant les annees70 a 90.
Sweroside can reduce the chlordecone plus CCL4 toxicity to liver and shows significant hepatoprotective effect [46] and sweroside-enriched herbal extract of Lonicera japonica could inhibit acetic acid-induced writhing, croton oil and arachidonic acid-induced ear edema, and carrageenan-induced rat hind paw hyperalgesia.
The best known imprinters from the environmental pollutants are lead, arsenic, cadmium, benzopyrene and various dioxins, furans, polychlorinated biphenyls and pesticides (DDT, DDE, methoxychlor, chlordecone, parathion, malathion, paraquat, cypermethrin and cyhalothrin).
However, this study is in variance with other works [12,17] that reported an increase in WBC when chlordecone was administered to male Sprague-Dawley rats [17] and when arsenic-poisoned cattle blood parameters were evaluated.
Washington, June 23 (ANI): Researchers have found that exposure to chlordecone (also named Kepone), an organochlorine chemical, can increase the risk of prostate cancer.
Meeting in Geneva, from 4 to 8 May, the 160 countries that are party to the convention decided to add to the first list of twelve substances already under strict international control the following substances: lindane; alpha hexachlorocyclohexane; beta hexachlorocyclohexane; hexabromodiphenyl ether and heptabromodiphenyl ether; tetrabromodiphenyl ether and pentabromodiphenyl ether; chlordecone; hexabromodiphenyl, pentachlorobenzene and perfluorooctane sulfonic acid.
Among its additions, the meeting decided to ban chlordecone, an agricultural pesticide, hexabromobiphenyl, an industrial flame retardant; and lindane, which many have used in insecticides for soil, wood and animals.
Concerns over the pesticide kepone, also known as chlordecone, emerged last year after a French medical researcher suggested it may have affected cancer rates in both overseas departments.