Also found in: Dictionary, Thesaurus, Wikipedia.
Related to Chlor-Trimeton: chlorpheniramine maleate, Piriton


trademark for preparations of chlorpheniramine maleate, an antihistamine.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

chlorpheniramine maleate

Ahist, Allercalm (UK), Allerief (UK), Calimol (UK), Chlorphen, Chlor-Trimeton, Chlor-Trimeton Allergy 4 Hour, Chlor-Trimeton Allergy 8 Hour, Chlor-Trimeton Allergy 12 Hour, Chlor-Tripolon (CA), Diabetic Tussin Allergy Relief, Novo-Pheniram (CA), Piriton (UK), Teldrin HBP

Pharmacologic class: Propylamine (nonselective)

Therapeutic class: Antihistamine; allergy, cold, and cough remedy

Pregnancy risk category B


Antagonizes effects of histamine at histamine2-receptor sites, preventing histamine-mediated responses


Capsules (sustained-release): 8 mg, 12 mg

Syrup: 1 mg/5 ml, 2 mg/5 ml, 2.5 mg/5 ml

Tablets: 4 mg, 8 mg, 12 mg

Tablets (chewable): 2 mg

Tablets (timed-release): 8 mg, 12 mg

Indications and dosages

Allergy symptoms; management of anaphylaxis and transfusion reactions

Adults: 4 mg q 4 to 6 hours P.O. or 8 to 12 mg P.O. of sustained-release form q 8 to 12 hours. Maximum dosage is 24 mg/day.

Children ages 6 to 12: 2 mg P.O. q 4 to 6 hours daily. Maximum dosage is 12 mg/day.

Dosage adjustment

• Glaucoma

• Gastric ulcer

• Hyperthyroidism

• Heart disease


• Hypersensitivity to drug

• Acute asthma attacks

• Stenosing peptic ulcer

• Breastfeeding


Use cautiously in:

• hepatic or renal disease, asthma, angle-closure glaucoma, prostatic hypertrophy

• elderly patients

• pregnant patients (safety not established).


• Don't crush or break timed-release tablets or sustained-release capsules.

• Discontinue drug 4 days before allergy skin tests. (Drug may cause false-negative reactions.)

Adverse reactions

CNS: dizziness, drowsiness, excitation (in children), sedation, poor coordination, fatigue, confusion, restlessness, nervousness, tremor, headache, hysteria, tingling sensation, sensation of heaviness and weakness in hands

CV: palpitations, hypotension, bradycardia, tachycardia, extrasystoles, arrhythmias

EENT: blurred vision, diplopia, vertigo, tinnitus, acute labyrinthitis, nasal congestion, dry nose, dry throat, sore throat

GI: nausea, vomiting, diarrhea, constipation, epigastric distress, anorexia, dry mouth, GI obstruction

GU: urinary retention, urinary hesitancy, dysuria, early menses, decreased libido, erectile dysfunction

Hematologic: hemolytic anemia, hypoplastic anemia, thrombocytopenia, leukopenia, pancytopenia, agranulocytosis

Respiratory: thickened bronchial secretions, chest tightness, wheezing

Skin: urticaria, rash, photosensitivity, diaphoresis

Other: chills, increased appetite, weight gain, anaphylactic shock


Drug-drug. Anticholinergics, anti-cholinergic-like drugs (such as some antidepressants, atropine, haloperidol, phenothiazines, quinidine, disopyramide): additive anticholinergic effects

CNS depressants (such as opioids, sedative-hypnotics): additive CNS depression

MAO inhibitors: intensified, prolonged anticholinergic effects

Drug-diagnostic tests. Allergy skin tests: false-negative reactions

Drug-behaviors. Alcohol use: additive CNS depression

Sun exposure: photosensitivity

Patient monitoring

• Assess for urinary retention and frequency.

• Monitor respiratory status throughout therapy.

Patient teaching

• Advise patient to take with full glass of water.

• Tell patient not to crush timed-release tablets or sustained-release capsules. Instruct him to swallow them whole.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Advise parents to give dose to children in evening, because morning doses may cause inattention in school.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


A trademark for the drug chlorpheniramine maleate.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
References in periodicals archive ?
"We want to let retailers know they can fill that gap on their shelves from Chlor-Trimeton 12 Hour with Chlorphen-12 or a private label equivalent," Pinkleton says.
* Take an over-the-counter antihistamine tablet, like Chlor-Trimeton, one half-hour before going outdoors.
Some popular antihistamines: Chlor-Trimeton or Triaminic (active ingredient: chlorpheniramine), Dimetapp (brompheniramine), Tavist (clemastine), and Benadryl (diphenhydramine).
But if an antihistamine is indicated, the best option is the oral first-generation drug chlorpheniramine, which is marketed over the counter under several names, including Chlor-Trimeton. If an injectable antihistamine is indicated, diphenhydramine (Benadryl) would be the first choice, according to Mr.
If an antihistamine is indicated, the best option is the oral first-generation drug chiorpheniramine, marketed over the counter under several names, including Chlor-Trimeton. If an injectable antihistamine is indicated, diphenhydramine (Benadryl) would be the first choice.
Chlor-trimeton (Ornade, Isochlor) Dimetane (Dimetapp), Benadryl, Tavist, Ambodryl, Clistin, Decapryn, Polaramine, Forhistal, Actidil (Actifed), PBZ, Histadyl, Tacaryl, Phenergan, Temaril, Atarax/Vistaril, Optimine, Periactin, Seldane, Hismanal, Claritin
Therefore, numerous combinations of antihistamines with decongestants are available: Actifed,(R)* A.R.M.,(R)* Chlor-Trimeton D,(R)* Contac,(R)* CoPyronil 2,(R)* Deconamine,(R)* Demazin,(R)* Dimetapp,(R)* Drixoral,(R)* Isoclor,(R)* Nolamine,(R) Novafed A,(R)* Ornade,(R) Sudafed Plus,(R) Tavist D,(R) Triaminic,(R)* Trinalin,(R) just to name a few.
26, 2015 in JAMA Internal Medicine, people who took high doses of tricyclic antidepressants such as doxepin (Sinequan), diphenhydramine (Benadryl), older antihistamines such as chlorpheniramine (Chlor-Trimeton), or antimuscarinic drugs for bladder control, such as oxybutynin (Ditropan) for longer than three years were significantly more likely to develop dementia.
In its petition to the FDA Well-Point cited the fact that many of today's current O-T-C antihistamines, including Actifed, Benadryl, Chlor-Trimeton and Dime-Tapp, were originally available only as prescriptions but have since been demonstrated safe and effective as nonprescription products.
A Allergists generally recommend that older adults avoid first-generation antihistamines such as diphenhydramine (Benadryl), chlorpheniramine (Chlor-Trimeton), dimenhydrinate (Dramamine), brompheniramine (Dimetapp and others), clemastine fumarate (Tavist, Allerhist), and dexbrompheniramine (Drixoral).
(35.1%) BEST-SELLING BRANDS Market Dollar sales Brand Manufacturer share (000) Benadryl Warner Wellcome 8.5% $51,576 Alka-Seltzer Plus Bayer 6.4% 38,929 Sudafed Warner Wellcome 5.2% 31,762 Theraflu Novartis 4.4% 26,715 Tylenol Cold McNeil 3.9% 23,375 Tylenol Sinus McNeil 3.7% 22,471 Tylenol Allergy McNeil 2.6% 20,487 Tavist D Novartis 2.6% 15,975 Contac SmithKline Beecham 2.5% 15,152 Chlor-Trimeton Schering-Plough 2.4% 14,795 Unit Sales BY TRADE CLASS Drug Stores 119.3 mil.