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a cytotoxic compound that causes severe damage to the adrenal cortex; administered orally as an antineoplastic agent for palliative treatment of inoperable adrenocortical carcinoma.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Lysodren® Oncology A cytotoxic agent that controls the endocrine Sx in Pts with adrenocortical CA and ACTH producing pituitary tumors that cause Cushing's disease Adverse effects Anorexia, N&V, neurologic disturbances–ataxia, speech defects, somnolence, vertigo, lethargy, liver enzyme changes–↑ ALA, ALT, alkaline phosphatase, GGT, ↑ corticosteroid-binding globulin, ↑ sex hormone-binding globulin, ↑ cholesterol, ↓ uric acid, ↓ thyroid hormones–normal TSH. See Adrenocortical carcinoma.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

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