Chlamydia trachomatis


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

Chla·myd·i·a tra·cho·ma·tis

spheric nonmotile bacteria that are obligatory intracellular organisms; they form compact intracytoplasmic microcolonies up to 10 mcm in diameter that (by division) give rise to infectious spherules 0.3 mcm or larger in diameter, accumulate glycogen for a limited period in sufficient quantity to be detected by iodine stain, and are usually susceptible to sulfadiazine, tetracycline, and quinalones; various strains of this species cause trachoma, inclusion and neonatal conjunctivitis, lymphogranuloma venereum, mouse pneumonitis, nonspecific urethritis, epididymitis, cervicitis, salpingitis, proctitis, and pneumonia; chief agent of bacterial sexually transmitted diseases in the U.S.; the type species of the genus Chlamydia.

Chlamydia trachomatis

STD A human pathogen, similar to gonorrhea in transmission and disease; it is found in the cervix and urethra and survives in the throat or rectum Epidemiology It is the most common STD agent in the US–causing ± 4.5 million cases/yr; it is present in 1-3% of all ♂ and 15-40% of ♀ in STD clinics Clinical Inclusion conjunctivitis, lymphogranuloma venereum, urethritis, epididymitis and proctitis in ♂, mucopurulent cervicitis, endometritis, salpingitis–C trachomatis is implicated in 50% of salpingitis and PID, bartholinitis, and acute urethral syndrome in ♀ and conjunctivitis and pneumonia in neonates; infection may be asymptomatic Diagnosis Direct fluorescent antibody staining, solid phase immunoassay, ELISA, cell culture, nucleic acid probe, PCR Complications Fallopian tube destruction, ±infertility, ectopic/tubal pregnancy, preterm delivery, severe PID Management Doxycycline, azithromycin. Cf Mycoplasma pneumoniae.

Chla·myd·i·a tra·cho·ma·tis

(klă-mi'dē-a trak-ō'mă-tis)
Spheric nonmotile organisms that accumulate glycogen and are susceptible to sulfadiazine and tetracycline; various strains of this species cause trachoma, inclusion and neonatal conjunctivitis, lymphogranuloma venereum, nonspecific urethritis, epididymitis, cervicitis, salpingitis, proctitis, and pneumonia; chief agent of bacterial sexually transmitted diseases in the U.S. The type species of the genus Chlamydia.

Chlamydia trachomatis

A species that causes a great variety of diseases, including genital infections in men and women. The diseases caused by C. trachomatis include conjunctivitis, epididymitis, lymphogranuloma venereum, pelvic inflammatory disease, pneumonia, trachoma, tubal scarring, and infertility.

C. trachomatis is a commonly sexually transmitted pathogen (causing more than a million chlamydial infections in the U.S. each year). Men with chlamydial infection experience penile discharge and discomfort while urinating. Women may be asymptomatic or may experience urethral or vaginal discharge, painful or frequent urination, lower abdominal pain, or acute pelvic inflammatory disease, which may result in infertility.

Transmission of the disease can be prevented by avoiding contact with infected people and by using condoms during intimate sex. A pregnant woman with a chlamydial infection can transmit the disease to her newborn during birth. In newborns, ophthalmic antibiotic solution should be instilled in the conjunctival sac of each eye to prevent neonatal conjunctivitis and blindness caused by Chlamydia.

Diagnosis

Several tests are available, including cultures, antigen detection assays, ligase chain reactions, polymerase chain reactions, and enzyme-linked immunoassays.

Treatment

Erythromycin, azithromycin, or tetracycline is effective.

CAUTION!

Tetracyclines are generally not recommended for pregnant women or children under 8 years old.
See also: Chlamydia
References in periodicals archive ?
The effect of urine testing in evaluations of the sensitivity of the Gen-Probe Aptima Combo 2 assay on endocervical swabs for Chlamydia trachomatis and Neisseria gonorrhoeae: the infected patient standard reduces sensitivity of single site evaluation.
El abstenerse de las relaciones sexuales es la unica forma segura de evitar la infeccion por Chlamydia trachomatis, dado que es muy comun estar infectado y no saberlo.
Polymerase chain reaction was used to analyse 355 urine samples from symptomatic and asymptomatic women for the presence of Chlamydia trachomatis. The samples were collected from two primary health-centres and two public universities in Bogota, Colombia.
Chlamydia trachomatis and risk of prevalent and incident cervical premalignancy in a population-based cohort.
Ultrastructural analysis of chlamydial antigen-containing vesicles everting from the Chlamydia trachomatis inclusion.
Active trachoma and ocular Chlamydia trachomatis infection in two Gambian regions: On course for elimination by 2020?
Ottun, "The association between Chlamydia trachomatis and ectopic pregnancy in Lagos, Nigeria--a case control study," Open Journal of Obstetrics and Gynecology, vol.
Trachomatis caused urethritis in 14 (14%) cases and the co-infection of Neisseria gonorrhoea and Chlamydia Trachomatis causing male urethritis is seen in 14 (14%) of the cases.
Probable case, either or both of the following: * A patient meeting the suspected case definition, in whom other causes of LGV-like symptoms (e.g., syphilis, gonorrhea, and herpes simplex virus) have been ruled out, and a positive Chlamydia trachomatis from culture or nucleic acid amplification test (NAAT) from a body site associated with symptoms.
Chlamydia trachomatis, L2 type strain 434/Bu (ATCC VR-902B) was used as the PCR positive control.
[USPRwire, Tue Mar 10 2015] Global Markets Direct's, 'Chlamydia Trachomatis Infections - Pipeline Review, H1 2015', provides an overview of the Chlamydia Trachomatis Infections's therapeutic pipeline.