There were 337 patients in the Marcaine group, and 92 patients in the Chirocaine
After observing the free flow of cerebrospinal fluid 15 mg levobupivacaine 0.5% (Chirocaine
(R) 0.5% levobupivacaine hydrochloride 5 mg/ml 10 ml Abbott Istanbul Turkey) was injected into subarachnoid space for 30 seconds.
(11) After the provocation test, a mixture of long-term corticosteroid (80 mg triamcinolone acetonide, Sinokort-A, IE, Istanbul, Turkey) and local anesthetic (4 cc levobupivocaine hydrochoride, Chirocaine
, Abbott Laboratories, Abbott Park, Illinois USA) was injected, and the injection site was closed.
Local anesthetics are given by injection or topically, and include benzocaine, bupivacaine (Marcaine, Sensorcaine), chloroprocaine (Nesacaine), camphor, dibucaine (Nuper-cainal), levobupivacaine (Chirocaine
), lidocaine (Xylocaine, Octocaine), mepivacaine (Carbocaine, Polocaine), pramoxine, prilocaine (Citanest), procaine (Novocaine), ropivacaine (Naropin), and tetracaine (Pontocaine).
In addition, although until 1998 Zeneca was not present in this market, in March 1998 it concluded an exclusive world-wide (except for Japan) agreement to license-in Chirocaine
, a longer-acting local anaesthetic.
Celltech, which also makes the anaesthetic Chirocaine
, is a favourite with the City as one of the few profitable biotech groups in Europe.
Celltech had good news about key products, saying that its US partner Purdue Pharma had launched an anaesthetic Chirocaine
in North America this year.
Furthermore, in the area of local anaesthetics (where Astra is the world market leader), Zeneca has undertaken to reverse all arrangements relating to Chirocaine
, a new long-acting local anaesthetic which Zeneca licensed-in last year.
After the orientation and visualization of nerve structures, 0.25% or 0.33% levobupivacaine (Chirocaine
5 mg/ml, Abbott) 1 ml/kg (2.5-3 mg/kg) was administered under direct ultrasonographic guidance with 'in-plane' technique and a 22G (Stimuplex[R]D, Braun) needle.
No one knows this better than Celltech, which had a disappointing pick up of new anaesthetic Chirocaine
Chiroscience yesterday also revealed it had signed a joint marketing deal with Abbott Laboratories Inc and Purdue Pharma for its anaesthetic Chirocaine
Celltech, which owns the anaesthetic Chirocaine
, fell 46p to pounds 13.10 after admitting that a skin treatment called Relaxin failed to work in tests.