(2013) Engineering the cellular protein secretory pathway for enhancement of recombinant tissue plasminogen activator expression in Chinese hamster ovary
cells: effects of CERT and XBP1s genes.
Transient Gene Expression (TGE) is a well-established technology for rapid production of milligram to gram quantities of recombinant proteins in Human Embryonic Kidney (HEK) and Chinese Hamster Ovary
(CHO) cell lines (1-3) Due to quick turnover and low cost, TGE platform plays more important role in bio pharmaceutical early development stages for two reasons; Firstly, it is essential for large biopharmaceutical companies to screen multiple drug candidates prior to moving forward into the formal development pipeline.
Growth behavior of Chinese hamster ovary
cells in a compact loop bioreactor 2.
1 Horse 1 V1 21 V2 21 2 Guinea pig 4 V3 21 V4 21 V5 21 3 Ferret 2 V6 21 V7 21 4 Ferret 2 V8 194 V9 194 V10 194 * HEK, human embryonic kidney cells; CHO, Chinese hamster ovary
leaf extract (LE) against DNA alkylations induced by ethylmethanesulphonate (EMS) in Chinese hamster ovary
 evaluated the potential genotoxicity of pure 2,4-D (acid), and the commercially used salt in Chinese hamster ovary
cells treated with 2.0-10.0 [micro]g/mL using SCE and single cell gel electrophoresis (SCGE) assays.
(1998) developed Super- CHO cell line (from Chinese Hamster Ovary
(CHO) parent cell line) which expressed recombinant IGF-I that renders the cells to grow indifinitely in protein and/or serum-free media.
SAFC(R), a custom manufacturing and services business unit of Sigma-Aldrich Corporation (NASDAQ: SIAL), is introducing the CHOZN(R) Platform system, a CHO (Chinese Hamster Ovary
) cell expression system.
Using their expertise in cell line, medium and feed development, raw material characterization, vendor qualification and supply chain management, the company is working to improve Chinese hamster ovary
(CHO) monoclonal platform cell lines and to redesign the way the platform processes are conceived and executed, and the company's off-the-shelf platform will include parental CHO cells genetically engineered for enhanced bioproduction, and chemically defined media and feeds designed to work in harmony with the cell lines.
Podansky et al identified altered glycosylation of insulin and insulin-like growth factor receptors in a Chinese hamster ovary
cell-line, which caused binding specificity to change for insulin (1).
Chinese hamster ovary
(CHO) cells are of great interest for bio processing and pharmaceutical research and development .
We further characterized the cholesterol efflux effect in Chinese hamster ovary