Chinese Hamster Ovary Cell


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A line of fibroblasts isolated in 1958, which is used in research, grows well in culture, and spontaneously transforms to a malignant morphology, due to cytoskeletal disorganization
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Initially while studying the activity of tumor suppressor p53 in Chinese hamster ovary cell line K1, we noticed in serendipity that mitotic inhibitor, colcemid, caused a moderate increase of UV-induced cell death [26].
Development of a serum-free culture medium for the large scale production of recombinant protein from a Chinese hamster ovary cell line.
"Proteomic profiling of a high-producing Chinese hamster ovary cell culture," Anal Chem.
A cloned recombinant Chinese hamster ovary cell line (CHO-EPO) manipulated to secrete recombinant human erythropoietin was used in this work.
Gu, et al., "Influence of Primatone RL Supplementation on Sialylation of Recombinant Human Interferon-g Produced by Chinese Hamster Ovary Cell Culture Using Serum-Free Media," Biotechnol.
Oligosaccharide structures present on asparagine-289 of recombinant human plasminogen expressed in a Chinese hamster ovary cell line.
Glutathione S-transferase in an arsenic-resistant Chinese hamster ovary cell line.
It was also decided that the mutant cell lines and the original Chinese Hamster Ovary cell line were possibly not apoptotic, that is, the cells do not participate in programmed cell death.
Mark Azam, VP of R & D and Operations of HumanZyme added, "Life science to date has been using proteins derived from bacteria and Chinese hamster ovary cells. There is a limit to how much we can understand humans using nonhuman tools," said Li.
Also, treating the Chinese hamster ovary cells with NAC can effectively inhibit cell apoptosis induced by radiation [19].
(2013) Engineering the cellular protein secretory pathway for enhancement of recombinant tissue plasminogen activator expression in Chinese hamster ovary cells: effects of CERT and XBP1s genes.
A report in Science Translational Medicine suggests that the antibody cocktail used in Ebola virus-infected patients can be further simplified to only two antibodies and that these antibodies can be produced in engineered Chinese hamster ovary cells. Such a cocktail protected nonhuman primates against the virus responsible for the 2014-2015 outbreak up to 3 days after exposure, and combining these antibodies with those specific for other strains may lead to a broad Ebola virus therapy.

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