The outcome measures included child-pugh score, ascites, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total billirubin, albumin, prothrombin time, platelet and white blood cells counts.
All the patients underwent clinical examination (according to a prepared check list) for the child-pugh score and ascites.
When those two variables, the treatment received, and the Child-Pugh score
were entered into the multivariate analysis, only a variceal size greater than 5 mm was associated independently with an increased risk of variceal bleeding.
The severity of the liver disease was measured in all patients by the Child-Pugh score (7).
05) with the severity of the liver disease measured by the Child-Pugh score in alcoholic cirrhotics (Fig.
The patients with YMDD mutations were significantly more likely to have an increased Child-Pugh score than were those without such mutations.
In a multicenter, double-blind, randomized study comprised of 85% males and 98% Asians, Child-Pugh scores increased significantly more in a placebo group of 215 patients than in a lamivudine (Epivir-HBV) group of 436 patients (8.
Additionally, of the 100 patients treated with BARACLUDE, 66 percent had an improvement or no worsening of the Child-Pugh Score
(which assesses severity of hepatic decompensation), with 32 percent of patients having achieved a 2-point reduction in Child-Pugh score
at Week 24; these rates were 61 percent and 35 percent, respectively, at Week 48.
Ribavirin must not be used in patients with a history of severe pre-existing cardiac disease, severe hepatic dysfunction or decompensated cirrhosis of the liver, autoimmune hepatitis, hemoglobinopathies, or in combination with peginterferon alfa-2a in HIV/HCV co-infected patients with cirrhosis and Child-Pugh score
The median Child-Pugh score
was 9 (range, 7-14), and the median bilirubin concentration was 36 [micro]mol/L (range, 6.
PEGASYS is also contraindicated in hepatic decompensation with Child-Pugh score
greater than or equal to 6 in cirrhotic CHC patients coinfected with HIV before or during treatment.
A total of thirty-two subjects were enrolled, including twenty four with cirrhosis (eight each Child-Pugh score
A, B, and C), and eight age- and gender-matched healthy subjects with normal hepatic function.