combinatorial library

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combinatorial library

A collection of chemical compounds, so designated because it has so many structures and variants that special methods are needed to catalogue, store and retrieve individual units—as in a real library.

Combinatorial libraries can exist as molecules free in solution linked to a solid substrate (e.g., a bead), or arranged on the surface of a microorganism. They are created either by split synthesis or parallel synthesis.

combinatorial library

in immunology, the ligation of cDNAs of light and heavy chains of immunoglobulins, each in a separate bacteriophage vector.
References in periodicals archive ?
ABIVAX's antiviral platform depends upon its technology of inhibition of mRNA biogenesis and its chemical library of nearly one thousand small molecules.
They address the core methodology used in computational drug discovery and selected applications, including the physical basis of ligand binding, the force field representation of biomolecular systems, and the concepts of chemical library representation and design, fragment libraries, drug-likeness, and filtering, as well as major in silico methods, such as ligand-based chemical library screening, pharmacophore modeling and screening, and ligand-protein docking.
The user-built chemical library enables customers to tailor the instrument to meet specific screening objectives.
8 million compounds kept in GSK's chemical library and their other drug discovery technologies.
The chemical library, created at the Broad Institute, comprises 100,000 customised molecules known as Diversity-Oriented Synthesis (DOS) compounds.
Over the past six years, several major life sciences organizations have worked on this project with IBM Research gaining access to a comprehensive chemical library extracted from worldwide patents and scientific abstracts.
We are not only able to identify neurogenic and neuroprotective compounds by screening against our cells, but we can also identify novel, patentable compounds, across a diverse chemical library.
Under terms of the agreement, Axxam will screen its extensive chemical library to identify compounds that can target specific ion channels in the immune system.
Although the sensors are finished, Ryan is still working on the chemical library and the software that will keep the ENose running in space.
As part of the agreement, Avexa will screen CSIRO Molecular and Health Technologies' chemical library across its many antiviral assays to identify compounds that are selectively active in preventing virus replication.
During the drug discovery process, systems will screen a huge chemical library, consisting of anywhere from one hundred thousand to one million chemical compounds, in order to search for chemical compounds effective in drug creation.
We have access to a chemical library of 100,000 different compounds.