combinatorial library

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combinatorial library

A collection of chemical compounds, so designated because it has so many structures and variants that special methods are needed to catalogue, store and retrieve individual units—as in a real library.

Combinatorial libraries can exist as molecules free in solution linked to a solid substrate (e.g., a bead), or arranged on the surface of a microorganism. They are created either by split synthesis or parallel synthesis.
References in periodicals archive ?
The partnership utilises Epizyme's HMT discovery platform, including its proprietary biology, biochemistry, chemical library, expertise, and intellectual property, to discover and develop HMT therapeutics against the set of targets included in the alliance.
The robot screened more than 120,000 potential compounds from a chemical library into individual micro-titer wells-a system used by drug companies called high-throughput screening-and automatically singled out those molecules found to have the biggest effects on the biological clock.
As part of the agreement, Avexa will screen CSIRO Molecular and Health Technologies' chemical library across its many antiviral assays to identify compounds that are selectively active in preventing virus replication.
It is designed to select and transport specified compounds from this large chemical library to workstations on the UHTSS Platform at a rate of more than 100,000 compounds per day for primary screening and 2,000 compounds per 1 dayfor re-testing and potency determination.
In the case of broad-based screening of a chemical library (typically consisting of over 30,000 compounds), as many as 1000 compounds can be tested per week if a fully automated test system is utilized.
Scientists, he says, "are only nowbeginning to appreciate and understand nature's chemical library involving organisms that mimic odors.'
Under the agreement, Eisai and Broad will collaborate together on drug discovery initiatives toward novel treatments for NTDs and tuberculosis through optimization of compounds screened from Broad's chemical library. The first project will conduct drug discovery research aimed at the creation of a novel treatment for Chagas disease, an NTD.
The current ToxCast chemical library covers approximately 17% of the chemicals subject to the EDSP, and the larger Tox21 chemical library covers approximately 53% of the chemicals subject to EDSP.
8 October 2010 - US Ligand Pharmaceuticals Inc (NASDAQ: LGND) said yesterday it has agreed to divest its combinatorial chemical library and associated proprietary technology to local research centre Venenum Biodesign LLC for USD1.8m (EUR1.3m).
Using a combination of molecular modeling and chemical library screening, the researchers created a novel compound that blocks the action of this protein.

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