chemical colitis


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An acute inflammatory colitis that follows ‘cleansing’ enemas; although classically associated with soapsuds, acute CC may also occur after rectal instillation of a wide range of ‘insulting fluids’ including herbal concoctions, H2O2, vinegar, potassium permanganate, sodium diatrizoate—Hypaque—glutaraldehyde, Fleet’s Phospho-Soda enema or inappropriate fluids, which may have hypertonic, detergent, or directly toxic effects

chemical colitis

Soap colitis An acute inflammatory colitis after a 'cleansing' enema; although classically associated with soapsuds, acute CC may also occur after rectal instillation of a wide range of 'insulting fluids' including herbal concoctions, H2O2, vinegar, potassium permanganate, sodium diatrizoate–Hypaque, glutaraldehyde, Fleet's Phospho-Soda enema or inappropriate fluids, which may have hypertonic, detergent, or directly toxic effects Clinical Pain, cramping, anaphylaxis, serosanguineous diarrhea, hypovolemia, hemoconcentration; if the mucosal damage is severe, bacteria may penetrate the mucosa, cause sepsis, hypokalemia, pseudomembrane formation, hemorrhagic necrosis, intestinal gangrene, and acute renal failure. See Colon therapy, Detoxification therapy, High colonic.
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In chemical colitis models such as dextran sodium sulfate- (DSS-) and trinitrobenzene sulfonic acid- (TNBS-) induced colitis, genetic mast cell deficiency or pharmacologic inhibition of mast cells ameliorated colitis [30, 35-41], while in another, mast cell deficiency had no effect on colitis [42].
Although deleterious in chemical colitis, mast cells may have a different effect in other colitis models that more closely replicate human IBD, for example, the [IL10.sup.-/-] mouse.
In line with the present study, BMP7 was shown to exert an anti-inflammatory effect in chemical colitis models [108, 109].