Ferrocene is known to readily form charge transfer complexes
(CTCs) with alkyl halides, as evidenced by the appearance of a feature indicative of a charge transfer complex at ~310 nm; subsequently, upon irradiation, the complex dissociates into the ferrocenium ion, chloride ion, and alkyl radical (Fig.
I developed Nuclear Magnetic Resonance facilities for the department, and worked on hydrogen bonding, charge transfer complexes
, and structural chemistry (with Stan Tarbell, a leader in antibiotics chemistry).
Keywords: Charge transfer complexes, Antihistamines, Curcumin, Benesi-Hildebrand plot
Regarding pharmaceutical chemistry, quantification of drug can be monitored by charge transfer complexes .
Therefore, it is of much importance and interesting to study the charge transfer complexes of drugs with various I or I-acceptors for qualitative and quantitative analysis of drugs in their pure form as well as in pharmaceutical formulations.
Furthermore, solid charge transfer complexes were synthesized and characterized by FT-IR spectroscopy.
Out of five newly formed charge transfer complexes, desloratadine and levocetirizine with curcumin appeared as deep red and pale yellow respectively, whereas promethazine, loratadine and diphenhydramine had yellowish-orange colour nearly similar to each other.
We have described a spectrophotometric method to determine five antihistaminic drugs (promethazine, desloratadine, levocetirizine, diphenhydramine and loratadine) via analysing their charge transfer complexes with curcumin in active pharmaceutical ingredients.
Sultana, Charge Transfer Complexes of Gamma Aminobutyric Acid-Analogue, A Neurotransmitter: Synthesis and Spectrophotometric Determination, J.