CHAR

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TFAP2B

A gene on chromosome 6p12 that encodes a member of the AP-2 family of transcription factors, which activate the transcription of genes involved in proper eye, face, body wall, limb and neural tube development. TFAP2B inhibits C/EBP alpha, MCAM/MUC18 and MYC; it appears to be required for normal face and limb development, and for proper terminal differentiation and function of renal tubular epithelia.

Molecular pathology
TFAP2B mutations cause autosomal dominant Char syndrome.
References in periodicals archive ?
And finally, just to throw the cat among the pigeons, the Newcastle historian Henry Bourne, in the early 20th century, claimed the street was originally called Budding Chare.
A view down a cobbled stretch of Pudding Chare, 1929.
Chares and Chabrias moved straightway to Chios, assisted by the Etesian winds which blow strongly across the Aegean during the months of early summer.
As to the timing of its conclusion we must look to the activities of Chares.
View down Pudding Chare showing the entrance to Wilson's Court, on the left, July 17, 1977
Looking down Pudding Chare to Collingwood Street, Newcastle, in November 1971