Peters-Kennedy, "Charcot-Leyden crystals
: do they exist in veterinary species?
Charcot-Leyden crystals (CLCs) are accepted as a morphologic hallmark of eosinophil-related disease in which there is active eosinophilic inflammation or proliferation.
Formation of Charcot-Leyden crystals in human eosinophils and basophils and study of the composition of isolated crystals.
Acute granulocytic leukemia may contain a variety of intracellular inclusions, including Auer rods, hexagonal or light green crystals, pseudo--Chediak-Higashi granules, Charcot-Leyden crystals
, and other unclassified inclusions.
The persistence of symptoms, required taking a second sample where isolating the fungus and visualizing fungal structures in the direct examination and the histopathology permitted establishing the diagnosis ofnon-invasive fungal sinusitis since allergic mucin with Charcot-Leyden crystals
were not observed, nor significant eosinophilia, or tissue or vascular invasion (4).
consist of a 13 000-molecular weight acidic protein whose amino acid composition distinguished it from the 9300-molecular weight major basic protein, the principal constituent of eosinophil large granules; this protein is identical to lysophospholipase (3) and is stained by basic fuchsin in the Ziehl-Neelsen method.
(5) They described this a s allergic mucin, which consisted of degenerating eosinophils, desquamated respiratory epithelial cells, and Charcot-Leyden crystals
. Fungal stains revealed fungal hyphae but no evidence of tissue invasion.
Inflammatory casts contain fibrin, eosinophils, and Charcot-Leyden crystals
; noninflammatory casts contain mucin and exhibit vascular hydrostatic changes.
New observations include Charcot-Leyden crystals
(Figure 4) and association with celiac disease, lupus anticoagulant, and new viral and bacterial infectious agents.