chalone

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chalone

 [kal´ōn]
a group of tissue-specific, water-soluble substances that are produced within a tissue and that inhibit mitosis of the cells of that tissue and whose action is reversible.

cha·lone

(kā'lōn),
Originally, a hormone (for example, enterogastrone) that inhibits rather than stimulates; now, mitotic inhibitor (often glycoproteins) elaborated by a tissue and active only on that type of tissue, regardless of species; thus, a reversible tissue-specific mitotic inhibitor.
[G. + chalaō, to relax, + -one]

chalone

(kā′lōn′, kăl′ōn′)
n.
Any of several polypeptides that cause the reversible inhibition of mitosis in the cells that secrete them.

cha·lone

(kal'ōn)
Any of a number of mitotic inhibitors elaborated by a tissue and active only on that type of tissue, regardless of species; a reversible tissue-specific mitotic inhibitor.
[G. + chalaō, to relax, + -one]

chalone

one of a group of chemicals (PEPTIDES and GLYCOPROTEINS) occurring in living animal tissues which specifically inhibit MITOSIS.
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