challenge

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challenge

 [chal´enj]
1. to administer a chemical substance to a patient for observation of whether the normal physiological response occurs.
2. in immunology, to administer antigen to evoke an immunologic response in a previously sensitized individual.
3. the administration of such a substance in order to assess for a response; called also provocation.
bronchial challenge (inhalational challenge) bronchial challenge test.

challenge

/chal·lenge/ (chal´enj)
1. to administer a substance to monitor for the normal physiological response.
2. in immunology, to administer an antigen to monitor the response in a sensitized person.

challenge

(chăl′ənj)
n.
Immunology The induction or evaluation of an immune response in an organism by administration of a specific antigen to which it has been sensitized.
v. chal·lenged, chal·lenging, chal·lenges
v.tr.
Immunology To induce or evaluate an immune response in (an organism) by administering a specific antigen to which it has been sensitized.

chal′lenge·a·ble adj.

challenge

1 a method of testing the sensitivity of an individual to a hormone, allergen, or other substance by administering a sample. A small amount may be injected to determine whether the immune system will react by producing appropriate antibodies.
2 a term used to describe the rapid or concentrated infusion of a substance such as potassium or magnesium in the face of a life-threatening deficiency or a rapid infusion of IV fluid to differentiate between fluid deficit or renal failure as the cause of severely decreased urine output.

challenge

Immunology The administration of an antigen or allergen to a person who has been previously exposed to the antigen, specifically to evoke an immune response

challenge,

n a stimulating or de-manding circumstance. To develop effective problem-solving skills and strategies, it is necessary to perceive such circumstance as inconvenience or burden instead of overwhelming impediments.
References in periodicals archive ?
He loves using his computer and the internet, otherwise he watches Challenge TV rather than CBeebies.
Darts ace Phil 'The Power' Taylor and ex-tennis hero Yevgeny Kafelnikov, now a professional poker player, are among the celebs that stand in Stevens' way in the grand final, screened live on Challenge TV tonight at 10pm.
He recently filmed a new series of Fort Boyard, which is currently being shown on digital channel Challenge TV.
Even if foreign groups were to invest heavily in Brazilian broadcast TV, it would take time to challenge TV Globo's commanding lead.
In the programme, Endurance UK on Challenge TV, contestants square up to see who can survive a shocking series of trials, including:
But the lanky TV star, who has twice been treated for alcoholism, stunned guests during the Challenge TV Game Show Awards at the Savoy Hotel by humiliating host Bob Monkhouse and lying flat on the floor for photographers.
Ultimate Poker Challenge TV Show -- Copyright and trademark infringement for use of WPTE footage and for superimposing the Ultimate Poker Challenge mark over the WORLD POKER TOUR mark.
At the moment Challenge TV is showing the 1992 series, and I caught a few minutes of it the other day and it is still an entertaining, fast paced quiz.
She worked for the Disney Channel, became the face of the National Lottery Daily Play on Challenge TV, hosted the EuroMillions draw and found time to do a Met Office meteorology course.
Most Saturdays I find myself plonked on the sofa, contentedly enjoying a re-run of Big Break on Challenge TV.
Catchphrase finally ended in September 2002 after 16 years because of declining ratings, but its Roy Walker heyday can still be seen on Challenge TV.

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