Chaikoff

Chai·koff

(shī'kof),
Israel Lyon, Polish-Canadian physician, 1902-1966. See: Wolff-Chaikoff block, Wolff-Chaikoff effect.
References in periodicals archive ?
In 1948, Wolff and Chaikoff showed that receiving a large amount of iodide stopped the organification of the thyroid cells in rats [7].
Chaikoff, "Plasma inorganic iodide as a homeostatic regulator of thyroid function," The Journal of Biological Chemistry, vol.
Chaikoff, "Disposition of the cholesterol moiety of a chylomicron-containing lipoprotein fraction of chyle in the rat," Journal of Lipid Research, vol.
Chaikoff, "The phosphorus-containing lipides of the carrot," The Journal of Biological Chemistry, vol.
The Wolff Chaikoff effect can occur, some may develop persistent hypo- or hyperthyroidism.
This is believed to be due partly to the escape from the Wolff-Chaikoff effect (acute inhibition of iodine organification) that is seen within days of exposure to excess iodide (Wolff and Chaikoff 1948).
The intent of Wolff and Chaikoff was to determine the effects of inorganic nonradioactive iodine on the thyroid gland in rats.
The first nail in the iodine coffin was the publication by Wolff and Chaikoff from UC Berkley in 1948, (11) describing their findings in rats administered iodide in increasing amounts by intraperitoneal injection.
(3) Wolff and Chaikoff acknowledged the excellent and dramatic results achieved consistently with the use of Lugol solution in hyperthyroidism.
The first nail in the iodine coffin was the publication by Wolff and Chaikoff from UC Berkley in 1948, (3) describing their finding in rats administered iodide in increasing amounts by intraperitoneal injection.
(27) The first paragraph of Stanley's manuscript stated the objective, "The interest of thyroidologists was recently aroused by the demonstration by Wolff and Chaikoff (1) that, with levels of serum iodide higher than 20 to 30 micrograms per cent, organic binding of iodine in the rat thyroid was inhibited.