cephamycin


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cephamycin

(sĕf-ă-mī′sĭn) [From cepha(losporin) + ″]
A group of antibiotics related to the second-generation cephalosporins, having increased bacterial activity against Enterobacteriaceae but diminished effectiveness against gram-positive bacteria. Members of this class of drugs, e.g., cefoxitin, cefotetan, are often used to treat mixed aerobic/anaerobic infections.
References in periodicals archive ?
Cephamycin cefoxitin, highly similar to cepahlosporins, presented better activity with a susceptibility rate of 56% (n = 77).
Confirmatory tests that detect cephamycin hydrolysis include the Amp-C disk test and the three-dimensional test.
Many isolates of Acinetobacter spp have developed resistance to antibiotics, including until now successful, aminopenicillins, ureidopenicillin, cefamandole and cephalothin, cephamycin, cefoxitin, most of the aminoglycosides, chloramphenicol, tetracycline, and the more recent antibiotics, such as cefotaxime, ceftazidime, imipenem, tobramycin, amikacin, and fluoroquinolones [17].
The antibiotic, Cephamycin C, was produced in SSF using wheat straw, deoiled cake of cotton seed, sunflower cake, and corn steep liquor [18] and wheat bran and sweet lemon peel was used as the substrate for the production of nigerloxin in SSF [19].
AmpC AY-lactamases are resistant to aminopenicillins carboxypenicillins ureidopenicillins cephalosporins broad as well as extended spectrum cephalosporins (cephamycin) and monobactams (aztreonam).23 AmpC AY-lactamases are resistant to AY-lactamase inhibitors like clavulanic acid.4 E.
[beta]-Lactam antibiotics are frequently used for Agrobacterium eradication in plant tissues, they are penicillin, cephalosporin, cephamycin, oxacephem, monobactam and carbapenem, and are currently being developed to improve and enlarge antibacterial activity (Demain and Elander, 1999).
CLSI mandates reporting methieillin-/oxacillin-resistant staphylococci resistant to all beta-lactam drugs--penicillins, cephalosporins, cephamycin, and beta-lactam/beta-lactam inhibitors and carbapenems.
Other successful preventive infection-control measures include strict hand washing and restricted use of cephalosporin and cephamycin antibiotics that promote resistance in Acinetobacter [22].
Cephamycin resistance in clinical isolates and laboratory-derived strains of Escherichia coli, Nova Scotia, Canada.
ESBLs are plasmid-mediated [beta]-lactamases that are capable of efficiently hydrolyzing penicillin, narrow and broad-spectrum cephalosporins and monobactams (aztreonam), but they do not hydrolyse cephamycin or carbapenems (imipenem, meropenem).
Even though the cephamycin antibiotics--cefotetan, cefmetazole, and cefoxitin--may appear to test susceptible, their usefulness in treating serious infections with ES[beta]L producers is unclear.