central pontine myelinolysis
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cen·tral pon·tine my·e·li·nol·y·sis
a sporadic disorder characterized by a localized area of demyelination in the center of the basis pontis that, on cross section, can vary substantially in size from one patient to another. In most instances, occurs concurrently with some other serious medical disorder (for example, chronic alcoholism, severe burns, advanced lymphomas); clinically may be asymptomatic or markedly symptomatic, depending on the size of the lesion.
central pontine myelinolysisA condition characterised by softening of the base of the brain at the pons with damage to the myelin sheath, related to aggressive correction of hyponatraemia. First identified in alcoholics (Wernicke-Korsakoff syndrome), CPM also occurs in AIDS, infection, lymphoproliferative disorders (e.g., AML), malnutrition, and post-stem cell transplantation venous obstruction.
Weakness, double vision, muscle spasms, speech defects, delirium, sleep disorders, hallucinations, tremors and uncontrolled eye movements.
Defects by MRI.
Slow correction of electrolytic imbalance.