central dogma


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cen·tral dog·ma

the proposition that while genetic information is transferred from parent to offspring via DNA duplication, within the cell, genetic information is transferred from DNA to mRNA (transcription) and then to protein (translation); proposed by Francis Crick.
The central dogma is the main thesis of molecular inheritance. In its simplest form, it states that DNA makes RNA, which makes protein; it is the pedagogical tenet that translation of a protein invariably follows a chain of molecular command, where DNA acts as the template for both its own replication and for the transcription to RNA—and, with subsequent maturation, to mRNA, which then serves as a template for translation into a protein

central dogma

Molecular biology The pedagogical tenet that translation of a protein invariably follows a chain of molecular command, where DNA acts as the template for both its own replication and for the transcription to RNA–and with subsequent maturation, to mRNA, which then serves as a template for translation into a protein. See DNA, Nucleic acid, Protein, Reverse transcription, RNA, RNA polymerase. Cf Prion.

central dogma

The proposition by Francis Crick (1916–) that, in genetics, the only possible progression was from DNA to RNA to protein. Embarrassingly, the discovery that retroviruses used RNA to make DNA demonstrated the riskiness of pronouncing dogmas in science.

central dogma

the hypothesis (based on WEISMANNISM) that genetical information flows only in one direction, from DNA to RNA to PROTEIN, and not in the opposite direction. Thus, in general, changes to protein structures produced by external forces are not inherited. See SOMATIC MUTATION. The hypothesis has, however, been modified to account for the activity of the enzyme REVERSE TRANSCRIPTASE, which transfers information ‘backwards’ from RNA to DNA.
References in periodicals archive ?
2) The central dogma in genetics is that individual genes (fixed sequences in the DNA) are copied to messenger RNA, which then exit the cell nucleus and attach to ribosomes.
The central dogma is the agreed upon framework for understanding the transfer of information within and in between living organisms.
The encoding/decoding processes of the algorithm are based on the central dogma of the molecular biology, and the processes are similar to the DNA transcription, splicing and RNA translation of the real organisms.
New research has shown that epigenomic (outside the genome) factors play a sizeable role in how living systems respond to their environment, thus circumventing the central dogma of biology.
The central dogma itself is relatively simple, although the chemical mechanisms underlying it are not.
The central dogma provides a model not just for cell function but, by extension, for evolution and adaptation as well.
The elucidation of the structure of DNA by Watson and Crick was unequivocally revolutionary for the field of biology, and the central dogma was the cornerstone on which molecular biology was constructed.
According to the central dogma of molecular biology, genes beget RNA molecules, and (usually) these beget proteins, which do most of the work in the cell.
The more religiously liberal theologians, willing to practice selective interpretation of doctrine, placed a premium on what they saw as the central dogma of their churches, namely, love and forgiveness.
In short, plate tectonics became the central dogma of geology, as evolution is of biology, the atomic theory is of chemistry, and the conservation laws are of physics.
He asserted that it revises a central dogma of molecular biology-that a protein molecule has one shape that predestines one biological function.

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