Because of their capacity to differentiate into osteoblasts,
cementoblasts, and fibroblasts, PDLCs were the first stem cells for periodontal tissue engineering.
(1,2) For resorption to occur, the protective barriers of the dental root, which are represented by the
cementoblasts and the pre-cementum, must be destroyed and an inflammatory process must be initiated.
Effects of mineral trioxide aggregate on cell survival, gene expression associated with mineralized tissues, and biomineralization of
cementoblasts. j Endod.
Numerous large
cementoblasts were evident around the calcified materials (figure 2 b).
Strontium promotes
cementoblasts differentiation through inhibiting sclerostin expression in vitro.
Interestingly, PDL cells exhibited a closer match to dental follicle cells in global gene expression profiles than did alveolar bone osteoblasts and
cementoblasts [10].
Benign cementoblastoma (BC) is a rare and benign odontogenic mesenchymal tumor, often characterized by the formation of cementum-like tissue produced by neoplastic
cementoblasts attached to or around the roots of a tooth.
They could be obtained from dental tissue and have shown multiple differentiation capacity and immunomodulation, capable of differentiating into both
cementoblasts and collagen forming cells [51].
When cultured in vitro, those stem cells differentiate to cells with the properties of
cementoblasts, cells synthesizing collagen, osteocytes and fibroblasts.
Hematoxylin and eosin stained sections showed prominent
cementoblasts, irregular lacunae, increased active
cementoblasts as can be seen in Figure 3(a).
Researchers reported that dental follicle cells change to other cells, such as
cementoblasts, osteoblasts, and periodontal ligament cells [10,11].
In contrast, increased inorganic phosphate in
cementoblasts up-regulates DMP1, osteopontin, NPP1 and ankylosis proteins, and down-regulates TNAP expression.
