"Effect of Cellulose Acetate Phthalate
(CAP) on Characteristics and Morphology of polysulfone/cellulose acetate phthalate (PSf/CAP) blend membranes".
The cellulose acetate phthalate
(CAP) due to its biocompatibility is used as enteric coating on capsules and tablets (22), (23), so that they do not dissolve until they reach the small intestine.
Cellulose acetate phthalate is a polymer used in the manufacturing of an enteric coating film or as agglutinant for tablets and capsules in which approximately one half of the hydroxyl groups is acetylated and approximately one fourth is esterified by one of the two acid groups (PODCZECK; JONES, 2004; ROWE et al., 2003).
The present study investigated the variation in the preparation of cellulose acetate phthalate and methacrylic acid copolymer coating (Rheapol L 100[R]), without drug addition, in a magistral pharmacy: standardized the pharmacotechnical procedures to coat hard gelatin capsules and evaluated the efficiency of such coating through disintegration tests.
Coating compositions comprised 8% (p/v) cellulose acetate phthalate, 1.5% (p/v) castor oil, 3% (p/v) propylenoglycol, 45% acetone and alcohol 96 GL to complete 100 mL (Formulation A/8).
Capsules were given four coating applications with cellulose acetate phthalate solution 8% (p/v)(A/8/4) and 4 and 5 applications with solutions 9 (A/9/4 and A/9/5) and 10% (p/v) (A/10/4 and A/10/5), respectively.
(2012) inappropriately referred to three polymers [polyvinyl acetate phthalate (PVAP), hypromellose phthalate (HMP), and cellulose acetate phthalate (CAP)] as "phthalates" and inappropriately implied that they are "phthalates" simply because they have the word "phthalate" in their names.
The chronic toxicity of cellulose acetate phthalate in rats and dogs.
Ihree phthalate polymers (hyptomellose phthalate, cellulose acetate phthalate
, and polyvinyl acetate phthalate) were noted in 75 RX products.
Phthalate polymers with no known toxicity-- hypromellose phthalate (HMP), cellulose acetate phthalate (CAP), and polyvinyl acetate phthalate (PVAP)--were included in 75 RX products.
Several different phthalates are currently used as excipients in approved pharmaceutical formulations: diethyl phthalate (DEP), dihutyl phthalate (DBP), dimethyl phthalate (DMP), dioctylphthalate (DOP), hypromellose phthalate (HMP), cellulose acetate phthalate (CAP), polyvinyl acetate phthalate (PVAP), and polyethylene terphthalate (PET) [Food and Drug Administration (FDA) 2010b].
Enteric coatings generally consist of various polymers, such as cellulose acetate phthalate
, cellulose acetate butyrate, ethylcellulose, polyvinyl acetate phthalate, and methacrylate copolymers.