cell adhesion molecule

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cell ad·he·sion mol·e·cule (CAM),

proteins that hold cells together, for example, uvomorulin, and hold them to their substrates, for example, laminin.
Farlex Partner Medical Dictionary © Farlex 2012

cell ad·he·sion mol·e·cule

(CAM) (sel ad-hē'zhŭn mol'ĕ-kyūl)
Proteins that hold cells together, e.g., uvomorulin, and hold them to their substrates, e.g., laminin.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

cell adhesion molecule



Any molecule that traverses the cell membrane and contains a chemical domain that binds it to other cells or to the extracellular matrix.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
The mentioned cellular adhesion molecules play a crucial role in the migration of leucocytes from the blood to the arterial intima (transendothelial route).
Association between platelet endothelial cellular adhesion molecule 1 (PECAM-1/ CD31) polymorphisms and acute myocardial infarction: a study in patients from Sicily.
Association of circulating cellular adhesion molecules with menopausal status and hormone replacement therapy: time-dependent change in transdermal, but not oral estrogen users.
Cytokine-induced expression of cellular adhesion molecules was measured on primary human coronary artery endothelial cell (HCAEC) cultures.
This process is mediated by cellular adhesion molecules such as sE-selectin, a specific product of endothelial cells.
[36] Recent studies have examined the role of cellular adhesion molecules in tumor metastasis, but no correlation was noted in the expression or distribution of various cellular adhesion molecules by the different histologic subtypes of basal cell carcinoma.
Intercellular adhesion molecule-1 (ICAM-1) and E-, P-, and L-selectin are cellular adhesion molecules involved in the recruitment of leukocytes on the activated vessel wall during inflammation (1) and play an important role in the early stages of atherosclerosis and its complications (2).
Several acute phase reactants, cytokines, and soluble cellular adhesion molecules have been implicated in this process, with their plasma concentrations increased in a variety of atherosclerotic diseases.
Soluble cellular adhesion molecules such as soluble intercellular adhesion molecule-1 (sICAM-1) are expressed on the surface of activated endothelial cells, in response to several inflammatory cytokines, to capture circulating leukocytes and increase the migration of white cells into the vascular intima.
For example, cytokines stimulate collagen synthesis in smooth muscle cells and promote endothelial and vascular smooth muscle cell activation through the induction of cellular adhesion molecules. Chemokines and growth factors such as monocyte chemoattractant protein-1 and M-CSF promote monocyte chemotaxis and attachment to the endothelium and support their survival and differentiation into macrophage-derived foam cells.
Because cellular adhesion molecules such as VCAM-1, intercellular adhesion molecule-1, and E-selectin and many cytokines and growth factors such as M-CSF contain functional DNA-binding sequences for NF-[kappa]B, AP-1, and egr-1, their expression is induced by the activation of these transcription factors (84).

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