cell-mediated immunity

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cell-·me·di·at·ed im·mu·ni·ty (CMI),

, cellular immunity
Immune responses mediated by activated, antigen-specific T lymphocytes. These T cells may function as effector cells or may orchestrate propagation of the inflammatory response and cellular recruitment through their secretion of cytokines and chemokines.
Synonym(s): delayed hypersensitivity (1)
Farlex Partner Medical Dictionary © Farlex 2012

cell-mediated immunity

Immunity resulting from a cell-mediated immune response. Also called cellular immunity.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

cell-me·di·at·ed im·mu·ni·ty

, cellular immunity (CMI) (sel'mē'dē-āt-ĕd i-myū'ni-tē, sel'yū-lăr)
Immune responses that are initiated by T lymphocytes and mediated by T lymphocytes, macrophages, or both (e.g., graft rejection, delayed-type hypersensitivity).
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
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cell-mediated immunity

Abbreviation: CMI.
The regulatory and cytotoxic activities of T cells during the specific immune response. This process requires about 36 hr to reach its full effect. Synonym: T-cell–mediated immunity See: illustration; humoral immunity

Unlike B cells, T cells cannot recognize foreign antigens on their own. Foreign antigens are recognized by antigen-presenting cells (APCs) such as macrophages, which engulf them and display part of the antigens on the APC's surface next to a histocompatibility or “self-” antigen (macrophage processing). The presence of these two markers, plus the cytokine interleukin-1 (IL-1) secreted by the APCs activates CD4 helper T cells (TH cells), which regulate the activities of other cells involved in the immune response.

CMI includes direct lysis of target cells by cytotoxic T cells, creation of memory cells that trigger a rapid response when a foreign antigen is encountered for the second time, and delayed hypersensitivity to tissue and organ transplants. T cells also stimulate the activity of macrophages, B cells, and natural killer cells. These functions are controlled largely by the secretion of lymphokines such as the interleukins, interferons, and colony-stimulating factors. Lymphokines facilitate communication and proliferation of the cells in the immune system.

See also: immunity
Medical Dictionary, © 2009 Farlex and Partners

cell-mediated immunity

Action by the immune system involving T cells (T LYMPHOCYTES) and concerned with protection against viruses, fungi, TUBERCULOSIS and cancers and rejection of foreign grafted material. Cell-mediated immunity is not primarily effected by ANTIBODIES.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
IFN-gamma ELISpot assay was employed to determine the MAGE-A1, MAGE-A3, or SSX-2-specific T cell response in peripheral blood of the NPC patients.
Researchers reported that rheumatoid PBMC cultured with CII produced increase amount of chemotactic factor in the majority of RA patients.14-16 Similar findings were recorded by other investigators using a variety of assay systems.17-19 In contrast, another researcher reported that increased T cell responses to CII were present in only a minority of patients with RA.20
The T cell response to haptenized proteins is antigen-specific and therefore the most unambiguous and informative endpoint for skin sensitization.
Since this factor is a multiplier to all load cell response readings R acquired for subsequent force calibration measurements, the standard uncertainty in R that is associated with the comparison calibrations of the multimeters with the simulator is
Summarising our results we have recognised that the cell response to molecules regulating cytokinetics as well as to lipid compounds is cell type-specific and may depend on the cell genetic background and the level of transformation.
Powell said, "I am optimistic that we have achieved a breakthrough in methods to prime a potent T cell response to individual MHC class II epitopes for various infectious diseases.
Boosting the antigen-specific T-helper cell response is critical to getting strong, prompt humoral and cytotoxic T-cell response for complete and rapid control of infection.
Finally, experimental data from studies in rhesus monkeys infected with Simian Immunodeficiency Virus (SIV) indicate that viral control is a function of the antiviral CD8 "F cell response.
The magnitude of the cytotoxic T lymphocyte activity at week 26 correlated with increased overall survival, indicating that Provenge evokes a memory T cell response that may play a role in the survival benefit of Provenge.
"We tested people's HLA molecules, which determine tissue type, and found that certain HLA types produce a strong T cell response that is associated with resistance to the disease, while other genetic variants are associated with a weaker T cell response, which led to poor protection," said Dr.
By bonding silk protein microfibers to a silk protein scaffold, researchers developed this composite that has high strength and bone formation-friendly cell response. The composite mimics the mechanical properties of natural bone.
Characteristics of the influenza virus-specific CD8+ T cell response in mice homozygous for disruption of the H-21Ab gene.